PMID- 22048062
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20220409
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Print)
IS  - 1471-003X (Linking)
VI  - 12
IP  - 12
DP  - 2011 Nov 3
TI  - Neurovascular pathways to neurodegeneration in Alzheimer's disease and other 
      disorders.
PG  - 723-38
LID - 10.1038/nrn3114 [doi]
AB  - The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or 
      vascular smooth muscle cells, glia and neurons. The NVU controls blood-brain 
      barrier (BBB) permeability and cerebral blood flow, and maintains the chemical 
      composition of the neuronal 'milieu', which is required for proper functioning of 
      neuronal circuits. Recent evidence indicates that BBB dysfunction is associated 
      with the accumulation of several vasculotoxic and neurotoxic molecules within 
      brain parenchyma, a reduction in cerebral blood flow, and hypoxia. Together, 
      these vascular-derived insults might initiate and/or contribute to neuronal 
      degeneration. This article examines mechanisms of BBB dysfunction in 
      neurodegenerative disorders, notably Alzheimer's disease, and highlights 
      therapeutic opportunities relating to these neurovascular deficits.
FAU - Zlokovic, Berislav V
AU  - Zlokovic BV
AD  - Department of Physiology and Biophysics, and Center for Neurodegeneration and 
      Regeneration at the Zilkha Neurogenetic Institute, University of Southern 
      California, Keck School of Medicine, 1501 San Pablo Street, Los Angeles, 
      California 90089, USA. bzlokovi@usc.edu
LA  - eng
GR  - R37 NS034467/NS/NINDS NIH HHS/United States
GR  - R01 HL063290/HL/NHLBI NIH HHS/United States
GR  - R37 NS34467/NS/NINDS NIH HHS/United States
GR  - R37 AG023084/AG/NIA NIH HHS/United States
GR  - HL63290/HL/NHLBI NIH HHS/United States
GR  - R01 NS034467/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111103
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
SB  - IM
MH  - Alzheimer Disease/*complications/pathology
MH  - Animals
MH  - Biological Transport/physiology
MH  - Blood-Testis Barrier/*physiopathology
MH  - Cerebrovascular Circulation/*physiology
MH  - Endothelium/physiopathology
MH  - Humans
MH  - Muscle, Smooth, Vascular/physiopathology
MH  - Myocytes, Smooth Muscle/pathology
MH  - Neurodegenerative Diseases/*etiology/*pathology
MH  - Pericytes/physiology
PMC - PMC4036520
MID - NIHMS582230
COIS- Competing interests statement The author declares competing financial interests: 
      see web version for details.
EDAT- 2011/11/04 06:00
MHDA- 2012/01/28 06:00
PMCR- 2014/05/28
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
PHST- 2014/05/28 00:00 [pmc-release]
AID - nrn3114 [pii]
AID - 10.1038/nrn3114 [doi]
PST - epublish
SO  - Nat Rev Neurosci. 2011 Nov 3;12(12):723-38. doi: 10.1038/nrn3114.