PMID- 22048611
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20211020
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 28
IP  - 1
DP  - 2013 Jan
TI  - The association between extracoronary calcification and coronary artery disease 
      in patients with type 2 diabetes mellitus.
PG  - 12-8
LID - 10.1007/s00380-011-0205-6 [doi]
AB  - Cardiovascular complications are the major cause of diabetes-associated morbidity 
      and mortality. However, not all patients with diabetes are at increased risk for 
      cardiovascular disease (CVD). Coronary artery calcification was found to be a 
      powerful predictor of coronary artery disease (CAD). The presence of 
      extracoronary cardiac calcification as a useful predictor of CAD is not yet 
      established, especially in type 2 diabetes mellitus (T2DM). The aim of this study 
      was to evaluate the relation between extracoronary calcification and extent of 
      CAD in a group of T2DM patients who were scheduled for computed tomographic 
      coronary angiography (CTCA). We prospectively studied 380 patients (151 had T2DM) 
      under the age of 60 years who were scheduled for CTCA because of suspected CAD. 
      Severity of CAD was assessed by Gensini score. Coronary artery calcium score 
      (CACS) as well as calcium score in the aortic valve, mitral annulus, ascending 
      aorta, and descending aorta were measured by a 256-row multidetector computed 
      tomography scanner with dedicated software for calcium calculation. Patients with 
      known CAD were excluded. Diabetic and nondiabetic patients had comparable age and 
      gender distribution. However, the diabetic group had higher Gensini score, CACS, 
      and extracoronary calcium score (ECCS). Logistic regression analyses identified 
      male gender and ECCS as significant predictors for the presence of CAD in 
      diabetic patients. Age, smoking, and ECCS were the significant predictors of CAD 
      in nondiabetic patients. Type 2 diabetic patients had increased coronary and 
      extracoronary calcification. ECCS was found to be a significant predictor of CAD 
      in diabetic and nondiabetic patients only when CACS was not taken into account.
FAU - Farrag, Azza
AU  - Farrag A
AD  - Cairo University, Cairo, Egypt. azzaabdelmoniem@yahoo.com
FAU - Bakhoum, Sameh
AU  - Bakhoum S
FAU - Salem, Mohammed Ali
AU  - Salem MA
FAU - El-Faramawy, Amr
AU  - El-Faramawy A
FAU - Gergis, Emmanuel
AU  - Gergis E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111103
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Aortic Diseases/diagnosis/epidemiology/*etiology
MH  - Calcinosis/diagnosis/epidemiology/*etiology
MH  - Calcium/*metabolism
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnosis/epidemiology/*etiology
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Egypt/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morbidity/trends
MH  - Prospective Studies
MH  - Risk Factors
MH  - Survival Rate/trends
MH  - Tomography, X-Ray Computed
EDAT- 2011/11/04 06:00
MHDA- 2013/07/03 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/06/06 00:00 [received]
PHST- 2011/09/30 00:00 [accepted]
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.1007/s00380-011-0205-6 [doi]
PST - ppublish
SO  - Heart Vessels. 2013 Jan;28(1):12-8. doi: 10.1007/s00380-011-0205-6. Epub 2011 Nov 
      3.