PMID- 22048789
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20170609
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 91
IP  - 5
DP  - 2012 May
TI  - Human herpesvirus 6 in biopsies from patients with gastrointestinal symptoms 
      after allogeneic stem cell transplantation.
PG  - 737-742
LID - 10.1007/s00277-011-1354-5 [doi]
AB  - Gastrointestinal complications are frequent after allogeneic stem cell 
      transplantation (allo-SCT). Main differential diagnoses are graft-versus-host 
      disease (GvHD) and viral infections. In this retrospective analysis, we included 
      50 patients with severe vomiting or diarrhea in the first year after allo-SCT. 
      One hundred two biopsies obtained by colonoscopy or endoscopy of the upper 
      gastrointestinal tract were analysed by conventional histology for signs of GvHD 
      and by qualitative polymerase chain reaction (PCR) for viral DNA of human 
      herpesvirus 6 (HHV-6) and other virus of the herpes family. DNA of HHV-6 was 
      detected in 38 of 75 initial samples (51%) and in 19 of 27 follow-up biopsies 
      (70%). In the initial samples (n = 75), HHV-6 DNA was detected in 20/37 (54%) 
      biopsies in the presence of GvHD compared to 18/38 (47%) biopsies without signs 
      of GvHD. At the time of the first endoscopic investigation, most patients 
      received antiviral prophylaxis with aciclovir. None of the follow-up biopsies was 
      HHV-6 DNA negative after antiviral treatment with aciclovir, foscarnet or 
      ganciclovir. By univariate analysis, no risk factor for HHV-6 detection could be 
      demonstrated. In this cohort of patients with severe gastrointestinal 
      complications, there was no significant difference in the overall survival 
      between patients with or without HHV-6 DNA detection in the gastrointestinal 
      tract. In summary, the detection of HHV-6 DNA had no impact on overall survival. 
      Moreover, antiviral therapy against HHV-6 was without effect. Thus, positive PCR 
      results in GI tract samples do not necessarily reflect reactivation of HHV-6. 
      Further studies are needed to define the significance of HHV-6 for GI tract 
      symptoms after allo-SCT.
FAU - Mousset, S
AU  - Mousset S
AD  - Medizinische Klinik II, J. W. Goethe-Universitat, Theodor Stern-Kai 7, 60590, 
      Frankfurt am Main, Germany. sabine.mousset@kgu.de.
FAU - Martin, H
AU  - Martin H
AD  - Medizinische Klinik II, J. W. Goethe-Universitat, Theodor Stern-Kai 7, 60590, 
      Frankfurt am Main, Germany.
FAU - Berger, A
AU  - Berger A
AD  - Institut fur Virologie, J. W. Goethe-Universitat, Frankfurt am Main, Germany.
FAU - Hess, S
AU  - Hess S
AD  - Medizinische Klinik II, J. W. Goethe-Universitat, Theodor Stern-Kai 7, 60590, 
      Frankfurt am Main, Germany.
FAU - Bug, G
AU  - Bug G
AD  - Medizinische Klinik II, J. W. Goethe-Universitat, Theodor Stern-Kai 7, 60590, 
      Frankfurt am Main, Germany.
FAU - Kriener, S
AU  - Kriener S
AD  - Institut fur Pathologie, J. W. Goethe-Universitat, Frankfurt am Main, Germany.
FAU - Engels, K
AU  - Engels K
AD  - Institut fur Pathologie, J. W. Goethe-Universitat, Frankfurt am Main, Germany.
FAU - Hoelzer, D
AU  - Hoelzer D
AD  - Medizinische Klinik II, J. W. Goethe-Universitat, Theodor Stern-Kai 7, 60590, 
      Frankfurt am Main, Germany.
FAU - Klein, S A
AU  - Klein SA
AD  - III. Medizinische Klinik, Universitatsklinikum Mannheim, Mannheim, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111103
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Gastrointestinal Diseases/pathology/*virology
MH  - Gastrointestinal Tract/pathology/virology
MH  - Graft vs Host Disease/pathology/*virology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Leukemia/complications/mortality/therapy
MH  - Middle Aged
MH  - Risk Factors
MH  - Roseolovirus Infections/diagnosis/*virology
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2011/11/04 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/06/12 00:00 [received]
PHST- 2011/10/08 00:00 [accepted]
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 10.1007/s00277-011-1354-5 [pii]
AID - 10.1007/s00277-011-1354-5 [doi]
PST - ppublish
SO  - Ann Hematol. 2012 May;91(5):737-742. doi: 10.1007/s00277-011-1354-5. Epub 2011 
      Nov 3.