PMID- 22049999 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20111104 IS - 0008-4166 (Print) IS - 0008-4166 (Linking) VI - 42 IP - 8 DP - 1996 Aug TI - Microbial transformation of 3,4-methylenedioxy-N-methylamphetamine and 3,4-methylenedioxyamphetamine. PG - 851-4 LID - 10.1139/m96-107 [doi] AB - The biotransformation of 3,4-methylenedioxy-N-methylarnphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) was examined in the fungus Cunninghamella echinulata. In addition to the reported mammalian metabolites (MDA, 3,4-methylenedioxybenzyl methyl ketoxime, 3,4-methylenedioxybenzyl methyl ketone) and the parent substrate, there were six novel metabolites detected. N-Acetyl-3,4-methylenedioxyamphetamine (NAcMDA) was unequivocally identified and three unidentified metabolites related to NAcMDA were also detected. N-Acetyl-3,4-methylenedioxy-1-phenyl-1-hydroxy-2-aminopropane was tentatively identified as a metabolite of MDMA. The only metabolite of MDA identified was NAcMDA. Two metabolites related to MDA remain unidentified.Key words: Cunninghamella, amphetamine, biotransformation, 3,4-methylenedioxy-N-methylamphetamine, 3,4-methylenedioxyamphetamine. FAU - Foster, B C AU - Foster BC FAU - Wilson, D L AU - Wilson DL FAU - Marwood, T AU - Marwood T FAU - Ethier, J C AU - Ethier JC FAU - Zamecnik, J AU - Zamecnik J LA - eng PT - Journal Article PL - Canada TA - Can J Microbiol JT - Canadian journal of microbiology JID - 0372707 EDAT- 1996/08/01 00:00 MHDA- 1996/08/01 00:01 CRDT- 2011/11/05 06:00 PHST- 2011/11/05 06:00 [entrez] PHST- 1996/08/01 00:00 [pubmed] PHST- 1996/08/01 00:01 [medline] AID - 10.1139/m96-107 [doi] PST - ppublish SO - Can J Microbiol. 1996 Aug;42(8):851-4. doi: 10.1139/m96-107.