PMID- 22050432
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20240323
IS  - 1747-0927 (Electronic)
IS  - 1747-0919 (Print)
IS  - 1747-0919 (Linking)
VI  - 6
IP  - 5-6
DP  - 2011
TI  - Theory of mind in schizophrenia: exploring neural mechanisms of belief 
      attribution.
PG  - 569-81
LID - 10.1080/17470919.2011.620774 [doi]
AB  - BACKGROUND: Although previous behavioral studies have shown that schizophrenia 
      patients have impaired theory of mind (ToM), the neural mechanisms associated 
      with this impairment are poorly understood. This study aimed to identify the 
      neural mechanisms of ToM in schizophrenia, using functional magnetic resonance 
      imaging (fMRI) with a belief attribution task. METHODS: In the scanner, 12 
      schizophrenia patients and 13 healthy control subjects performed the belief 
      attribution task with three conditions: a false belief condition, a false 
      photograph condition, and a simple reading condition. RESULTS: For the false 
      belief versus simple reading conditions, schizophrenia patients showed reduced 
      neural activation in areas including the temporoparietal junction (TPJ) and 
      medial prefrontal cortex (MPFC) compared with controls. Further, during the false 
      belief versus false photograph conditions, we observed increased activations in 
      the TPJ and the MPFC in healthy controls, but not in schizophrenia patients. For 
      the false photograph versus simple reading condition, both groups showed 
      comparable neural activations. CONCLUSIONS: Schizophrenia patients showed reduced 
      task-related activation in the TPJ and the MPFC during the false belief condition 
      compared with controls, but not for the false photograph condition. This pattern 
      suggests that reduced activation in these regions is associated with, and 
      specific to, impaired ToM in schizophrenia.
FAU - Lee, Junghee
AU  - Lee J
AD  - Semel Institute for Neuroscience and Human Behavior, University of California 
      (UCLA), Los Angeles, CA 90095-6968, USA. jungheelee@ucla.edu
FAU - Quintana, Javier
AU  - Quintana J
FAU - Nori, Poorang
AU  - Nori P
FAU - Green, Michael F
AU  - Green MF
LA  - eng
GR  - MH065707/MH/NIMH NIH HHS/United States
GR  - MH043292/MH/NIMH NIH HHS/United States
GR  - R01 MH065707/MH/NIMH NIH HHS/United States
GR  - R01 MH043292/MH/NIMH NIH HHS/United States
GR  - R29 MH043292/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Soc Neurosci
JT  - Social neuroscience
JID - 101279009
SB  - IM
MH  - Adult
MH  - *Brain Mapping
MH  - *Culture
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Schizophrenia/*physiopathology
MH  - *Schizophrenic Psychology
MH  - Theory of Mind/*physiology
MH  - Young Adult
PMC - PMC3928144
MID - NIHMS547265
EDAT- 2011/11/05 06:00
MHDA- 2012/03/01 06:00
PMCR- 2014/02/18
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PHST- 2014/02/18 00:00 [pmc-release]
AID - 10.1080/17470919.2011.620774 [doi]
PST - ppublish
SO  - Soc Neurosci. 2011;6(5-6):569-81. doi: 10.1080/17470919.2011.620774.