PMID- 22052208
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20111215
IS  - 1096-8644 (Electronic)
IS  - 0002-9483 (Linking)
VI  - 147
IP  - 1
DP  - 2012 Jan
TI  - Evaluating ring-tailed lemurs (Lemur catta) from southwestern Madagascar for a 
      genetic population bottleneck.
PG  - 21-9
LID - 10.1002/ajpa.21603 [doi]
AB  - In light of historical and recent anthropogenic influences on Malagasy primate 
      populations, in this study ring-tailed lemur (Lemur catta) samples from two sites 
      in southwestern Madagascar, Beza Mahafaly Special Reserve (BMSR) and 
      Tsimanampetsotsa National Park (TNP), were evaluated for the genetic signature of 
      a population bottleneck. A total of 45 individuals (20 from BMSR and 25 from TNP) 
      were genotyped at seven microsatellite loci. Three methods were used to evaluate 
      these populations for evidence of a historical bottleneck: M-ratio, mode-shift, 
      and heterozygosity excess tests. Three mutation models were used for 
      heterozygosity excess tests: the stepwise mutation model (SMM), two-phase model 
      (TPM), and infinite allele model (IAM). M-ratio estimations indicated a potential 
      bottleneck in both populations under some conditions. Although mode-shift tests 
      did not strongly indicate a population bottleneck in the recent historical past 
      when samples from all individuals were included, a female-only analysis indicated 
      a potential bottleneck in TNP. Heterozygosity excess was indicated under two of 
      the three mutation models (IAM and TPM), with TNP showing stronger evidence of 
      heterozygosity excess than BMSR. Taken together, these results suggest that a 
      bottleneck may have occurred among L. catta in southwestern Madagascar in the 
      recent past. Given knowledge of how current major stochastic climatic events and 
      human-induced change can negatively impact extant lemur populations, it is 
      reasonable that comparable events in the historical past could have caused a 
      population bottleneck. This evaluation additionally functions to highlight the 
      continuing environmental and anthropogenic challenges faced by lemurs in 
      southwestern Madagascar.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Parga, Joyce A
AU  - Parga JA
AD  - Department of Social Sciences, University of Toronto at Scarborough, ON, Canada. 
      j.parga@utoronto.ca
FAU - Sauther, Michelle L
AU  - Sauther ML
FAU - Cuozzo, Frank P
AU  - Cuozzo FP
FAU - Jacky, Ibrahim Antho Youssouf
AU  - Jacky IA
FAU - Lawler, Richard R
AU  - Lawler RR
LA  - eng
PT  - Journal Article
DEP - 20111103
PL  - United States
TA  - Am J Phys Anthropol
JT  - American journal of physical anthropology
JID - 0400654
SB  - IM
MH  - Animals
MH  - Bayes Theorem
MH  - Ecosystem
MH  - Female
MH  - *Genetic Variation
MH  - Genetics, Population
MH  - Heterozygote
MH  - Lemur/*genetics
MH  - Madagascar
MH  - Male
MH  - Microsatellite Repeats
MH  - *Models, Genetic
MH  - Mutation
EDAT- 2011/11/05 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/05 06:00
PHST- 2010/11/16 00:00 [received]
PHST- 2011/07/19 00:00 [accepted]
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1002/ajpa.21603 [doi]
PST - ppublish
SO  - Am J Phys Anthropol. 2012 Jan;147(1):21-9. doi: 10.1002/ajpa.21603. Epub 2011 Nov 
      3.