PMID- 22053291 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20111110 LR - 20211020 IS - 2233-8268 (Electronic) IS - 2233-8276 (Print) IS - 2233-8276 (Linking) VI - 1 IP - 1 DP - 2011 Apr TI - Immunoglobulin E in health and disease. PG - 12-5 LID - 10.5415/apallergy.2011.1.1.12 [doi] AB - The discovery of immunoglobulin E (IgE) was a breakthrough in the field of Allergy and Immunology. Our understanding of mechanisms of allergic reactions and the role of IgE in these disorders has paralleled to the discovery of treatment modalities for patients with allergy. Apart from allergic diseases, IgE is involved in pathogenesis of other disorders. Much controversy exists about the control of total IgE (tIgE) levels and allergen-specific IgE (sIgE) profiles in allergic individuals. This review aims at giving a comprehensive overview of IgE molecule and discussing the issues related to its importance in clinical setting. FAU - Amarasekera, M AU - Amarasekera M AD - Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka. LA - eng PT - Journal Article DEP - 20110419 PL - Netherlands TA - Asia Pac Allergy JT - Asia Pacific allergy JID - 101561954 PMC - PMC3206235 OTO - NOTNLM OT - Allergy OT - Immunoglobulin E EDAT- 2011/11/05 06:00 MHDA- 2011/11/05 06:01 PMCR- 2011/04/01 CRDT- 2011/11/05 06:00 PHST- 2010/11/18 00:00 [received] PHST- 2010/11/28 00:00 [accepted] PHST- 2011/11/05 06:00 [entrez] PHST- 2011/11/05 06:00 [pubmed] PHST- 2011/11/05 06:01 [medline] PHST- 2011/04/01 00:00 [pmc-release] AID - 10.5415/apallergy.2011.1.1.12 [doi] PST - ppublish SO - Asia Pac Allergy. 2011 Apr;1(1):12-5. doi: 10.5415/apallergy.2011.1.1.12. Epub 2011 Apr 19.