PMID- 22053300
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2233-8268 (Electronic)
IS  - 2233-8276 (Print)
IS  - 2233-8276 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jul
TI  - The role of allergic risk and other factors that affect the occurrence of atopic 
      dermatitis in the first 6 months of life.
PG  - 73-9
LID - 10.5415/apallergy.2011.1.2.73 [doi]
AB  - BACKGROUND: Atopic dermatitis (AD) is a chronic inflammation of the skin that 
      often appears in early childhood. The manifestation is related to the tendency 
      towards T helper 2 cytokine immune responses (interleukin (IL)-4, IL-5). Genetic 
      factors are suggested to play important roles in AD, and it can be transmitted to 
      newborns, increasing their risk of developing allergies. OBJECTIVE: To determine 
      the association between cord-blood cytokine levels (IL-5, interferon (IFN) gamma), 
      cord-blood total immunoglobulin E (IgE) level, perinatal environmental exposure, 
      and the risks of allergy as well as the development of AD in the first 6 months 
      of life. METHODS: A 6-month cohort study with a nested case-control within was 
      conducted on newborns in Jakarta from December 2008 until May 2009. After the 
      umbilical cord blood samples were taken and stored, subjects were followed up 
      monthly until 6 months old. The occurrence of AD and lifestyle or environmental 
      exposures were recorded. The allergic risk was determined using a modified 
      pediatric allergy immunology work groups scoring system based on allergic history 
      (allergic rhinitis, asthma, AD) in the family. The levels of IL-5 and IFN-gamma were 
      measured using ELISA and total IgE by CAP system FEIA. Multivariate analysis was 
      used to evaluate risk factors. RESULTS: This study was conducted on 226 subjects. 
      The incidence of AD was 16.4%; of those, 59% had low risk allergy, 38.5% 
      moderate, and 2% high risk. AD mostly occurred at the age of 1 month (57%). Cord 
      blood samples were examined in 37 subjects with AD and 51 without AD; of those, 
      25% showed high levels of total IgE (>1.2 IU/microL), and 51% showed 
      normally-distributed high absorbance IL-5 values (>/=0.0715, absolute value was 
      undetected). The increased level of IL-5 was directly proportional to IgE. High 
      absorbance IFN-gamma values (>/=0.0795, absolute value = 18.681 pg/microL) were observed in 
      52% of subjects. CONCLUSION: The associations between the risk of allergy in the 
      family, cord-blood total IgE, IL-5, IFN levels, and some perinatal environmental 
      exposure with AD in the first 6 months of life have not been established.
FAU - Munasir, Zakiudin
AU  - Munasir Z
AD  - Department of Child Health, Cipto Mangunkusumo Hospital - Faculty of Medicine, 
      University of Indonesia, Jakarta 10430, Indonesia.
FAU - Sastroasmoro, Sudigdo
AU  - Sastroasmoro S
FAU - Djauzi, Samsuridjal
AU  - Djauzi S
FAU - Waspadji, Sarwono
AU  - Waspadji S
FAU - Ramelan, Wahyuning
AU  - Ramelan W
FAU - Aminullah, Asril
AU  - Aminullah A
FAU - Widowati, Retno
AU  - Widowati R
FAU - Harahap, Alida Roswita
AU  - Harahap AR
FAU - Endaryanto, Anang
AU  - Endaryanto A
FAU - Wahidiyat, Iskandar
AU  - Wahidiyat I
LA  - eng
PT  - Journal Article
DEP - 20110728
PL  - Netherlands
TA  - Asia Pac Allergy
JT  - Asia Pacific allergy
JID - 101561954
PMC - PMC3206252
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - IFN-gamma
OT  - IL-4 genetic polymorphism
OT  - IL-5
OT  - IgE
OT  - Risk factor of allergy
EDAT- 2011/11/05 06:00
MHDA- 2011/11/05 06:01
PMCR- 2011/07/01
CRDT- 2011/11/05 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/05/11 00:00 [accepted]
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2011/11/05 06:01 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.5415/apallergy.2011.1.2.73 [doi]
PST - ppublish
SO  - Asia Pac Allergy. 2011 Jul;1(2):73-9. doi: 10.5415/apallergy.2011.1.2.73. Epub 
      2011 Jul 28.