PMID- 22055774
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20220410
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1427
DP  - 2012 Jan 3
TI  - Impulse noise exposure in rats causes cognitive deficits and changes in 
      hippocampal neurotransmitter signaling and tau phosphorylation.
PG  - 35-43
LID - 10.1016/j.brainres.2011.08.035 [doi]
AB  - Noise exposure has been characterized as a stressor, and its non-auditory effects 
      on the central nervous system have been established both epidemiologically and 
      experimentally. Little is known about the impact of impulse noise on the brain, 
      however. In this study, we examined the effects of impulse noise stress on 
      spatial learning and memory and on associated changes in the hippocampus. Rats 
      were exposed to 20 sound impulses with a peak sound pressure of 165 dB and 
      duration of 100 ms. Impulse noise stress led to a temporary decrease in cognitive 
      function as evidenced by poor spatial memory in the Morris water maze (MWM). 
      Effects of noise on the glutamate (Glu)-N-methyl-D-aspartic acid receptor (NMDAR) 
      signaling system and hippocampal tau phosphorylation were investigated by high 
      performance liquid chromatography, Western blotting, and immunohistochemistry. 
      The concentrations of Glu and aspirate (Asp) in the hippocampus were increased at 
      30 min after exposure and remained elevated for the entire observation period (24 
      h), while the content of glycine (Gly) was stable for several hours following 
      noise but also increased by 24 h after noise stress. Impulse noise stress also 
      caused a significant increase in NMDAR 2B subunit (NR2B) expression and a 
      two-phase increase in tau phosphorylation in hippocampus. Immunohistochemistry 
      confirmed tau hyperphosphorylation in hippocampus that was most prominent in the 
      dentate gyrus (DG) and CA1 region. These findings demonstrate that impulse noise 
      stress impairs early spatial memory, possibly by disrupting Glu-NMDAR signaling 
      and triggering aberrant tau hyperphosphorylation in hippocampus.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Cui, Bo
AU  - Cui B
AD  - Department of Occupational Hygiene, Institute of Health and Environmental 
      Medicine, Academy of Military Medical Sciences, Tianjin, PR China.
FAU - Wu, Mingquan
AU  - Wu M
FAU - She, Xiaojun
AU  - She X
FAU - Liu, Hongtao
AU  - Liu H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110819
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Phosphoproteins)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Animals
MH  - Cognition Disorders/etiology/*metabolism/physiopathology
MH  - Disease Models, Animal
MH  - Hippocampus/*metabolism/physiopathology
MH  - Male
MH  - Neurotransmitter Agents/*physiology
MH  - Noise/*adverse effects
MH  - Phosphoproteins/*metabolism/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/*physiology
MH  - Stress, Physiological/physiology
MH  - tau Proteins/*metabolism/physiology
EDAT- 2011/11/08 06:00
MHDA- 2012/05/12 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/05/12 00:00 [received]
PHST- 2011/08/04 00:00 [revised]
PHST- 2011/08/13 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - S0006-8993(11)01540-X [pii]
AID - 10.1016/j.brainres.2011.08.035 [doi]
PST - ppublish
SO  - Brain Res. 2012 Jan 3;1427:35-43. doi: 10.1016/j.brainres.2011.08.035. Epub 2011 
      Aug 19.