PMID- 22055931
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20151119
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Jan
TI  - Cardiac magnetic resonance imaging predicts recovery of left ventricular function 
      in acute onset cardiomyopathy.
PG  - 30-5
LID - 10.1016/j.hlc.2011.09.005 [doi]
AB  - BACKGROUND: In acute onset cardiomyopathy, acute myocarditis is an important 
      cause, as it is associated with a greater likelihood of recovery of cardiac 
      function and its presence may direct specific therapies. Myocarditis can be 
      detected by cardiac magnetic resonance imaging (CMR); however its diagnostic 
      utility and relation to prognosis in acute onset cardiomyopathy are unknown. 
      METHODS: We performed CMR on 61 patients with acute onset cardiomyopathy and a 
      left ventricular ejection fraction (LVEF) <55%. CMR included assessment of 
      myocardial function, relative myocardial oedema, myocardial inflammation (using 
      global relative enhancement [GRE] of the myocardium 4 minutes post Gad-DTPA 
      contrast) and necrosis or fibrosis (with late gadolinium enhancement [LGE]). 
      Patients were followed up at six months to evaluate LVEF, morbidity and 
      mortality. RESULTS: There was a greater improvement in LVEF at follow up in those 
      with myocardial inflammation identified by elevated GRE compared to those without 
      (mean increase 19.2+/-2.5% vs. 6.7+/-1.7%, p<0.001). However, the presence of 
      myocardial oedema or LGE alone was not associated with a greater recovery of LVEF 
      (p=NS for both). Myocardial inflammation in patients with a baseline LVEF<35% was 
      also associated with a greater recovery of LVEF (mean increase 21.5+/-2.9% vs. 
      9.1+/-3.0%, p<0.01). CONCLUSION: Myocardial inflammation identified by an elevated 
      GRE predicts recovery of LV function in patients with acute onset cardiomyopathy.
CI  - Copyright (c) 2011 Australasian Society of Cardiac and Thoracic Surgeons and the 
      Cardiac Society of Australia and New Zealand. Published by Elsevier B.V. All 
      rights reserved.
FAU - McLellan, Alex J A
AU  - McLellan AJ
AD  - The Alfred Hospital, Melbourne, Victoria, Australia; St Vincent's Hospital, 
      Melbourne, Victoria, Australia.
FAU - McKenzie, Scott C
AU  - McKenzie SC
FAU - Taylor, Andrew J
AU  - Taylor AJ
LA  - eng
PT  - Journal Article
DEP - 20111103
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Cardiomyopathies/*diagnosis/etiology/pathology/physiopathology
MH  - Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Inflammation/complications/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Recovery of Function
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/diagnosis/physiopathology
EDAT- 2011/11/08 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/06/28 00:00 [received]
PHST- 2011/08/24 00:00 [revised]
PHST- 2011/09/10 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - S1443-9506(11)01194-2 [pii]
AID - 10.1016/j.hlc.2011.09.005 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2012 Jan;21(1):30-5. doi: 10.1016/j.hlc.2011.09.005. Epub 2011 
      Nov 3.