PMID- 22056201 OWN - NLM STAT- MEDLINE DCOM- 20120417 LR - 20240417 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 134 IP - 1 DP - 2012 Jan TI - Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study. PG - 1-9 LID - 10.1016/j.schres.2011.10.005 [doi] AB - Emotion processing deficits are prominent in schizophrenia and exist prior to the onset of overt psychosis. However, developmental trajectories of neural circuitry subserving emotion regulation and the role that they may play in illness onset have not yet been examined in patients at risk for psychosis. The present study employed a cross-sectional analysis to examine age-related functional activation in amygdala and prefrontal cortex, as well as functional connectivity between these regions, in adolescents at clinical high risk (CHR) for psychosis relative to typically developing adolescents. Participants (n=34) performed an emotion processing fMRI task, including emotion labeling, emotion matching, and non-emotional control conditions. Regression analyses were used to predict activation in the amygdala and ventrolateral prefrontal cortex (vlPFC) based on age, group, sex, and the interaction of age by group. CHR adolescents exhibited altered age-related variation in amygdala and vlPFC activation, relative to controls. Controls displayed decreased amygdala and increased vlPFC activation with age, while patients exhibited the opposite pattern (increased amygdala and decreased vlPFC activation), suggesting a failure of prefrontal cortex to regulate amygdala reactivity. Moreover, a psychophysiological interaction analysis revealed decreased amygdala-prefrontal functional connectivity among CHR adolescents, consistent with disrupted brain connectivity as a vulnerability factor in schizophrenia. These results suggest that the at-risk syndrome is marked by abnormal development and functional connectivity of neural systems subserving emotion regulation. Longitudinal data are needed to confirm aberrant developmental trajectories intra-individually and to examine whether these abnormalities are predictive of conversion to psychosis, and of later deficits in socioemotional functioning. CI - Copyright (c) 2011 Elsevier B.V. All rights reserved. FAU - Gee, Dylan G AU - Gee DG AD - University of California, Los Angeles, Department of Psychology, Los Angeles, CA 90095-1563, USA. FAU - Karlsgodt, Katherine H AU - Karlsgodt KH FAU - van Erp, Theo G M AU - van Erp TG FAU - Bearden, Carrie E AU - Bearden CE FAU - Lieberman, Matthew D AU - Lieberman MD FAU - Belger, Aysenil AU - Belger A FAU - Perkins, Diana O AU - Perkins DO FAU - Olvet, Doreen M AU - Olvet DM FAU - Cornblatt, Barbara A AU - Cornblatt BA FAU - Constable, Todd AU - Constable T FAU - Woods, Scott W AU - Woods SW FAU - Addington, Jean AU - Addington J FAU - Cadenhead, Kristin S AU - Cadenhead KS FAU - McGlashan, Thomas H AU - McGlashan TH FAU - Seidman, Larry J AU - Seidman LJ FAU - Tsuang, Ming T AU - Tsuang MT FAU - Walker, Elaine F AU - Walker EF FAU - Cannon, Tyrone D AU - Cannon TD CN - NAPLS Consortium LA - eng GR - MH081902/MH/NIMH NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - MH818576/MH/NIMH NIH HHS/United States GR - P50 MH066286/MH/NIMH NIH HHS/United States GR - MH81988/MH/NIMH NIH HHS/United States GR - MH82022/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - U01 MH076989/MH/NIMH NIH HHS/United States GR - MH82004/MH/NIMH NIH HHS/United States GR - U01 MH081902-04/MH/NIMH NIH HHS/United States GR - MH81928/MH/NIMH NIH HHS/United States GR - MH81944/MH/NIMH NIH HHS/United States GR - MH81984/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States GR - U01 MH081944/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20111106 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Amygdala/*physiopathology MH - Case-Control Studies MH - Cross-Sectional Studies MH - Emotions/*physiology MH - Facial Expression MH - Female MH - Functional Laterality/physiology MH - Functional Neuroimaging MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Neural Pathways/physiopathology MH - Pattern Recognition, Visual/*physiology MH - Prefrontal Cortex/*physiopathology MH - Psychotic Disorders/*physiopathology MH - Schizophrenia/physiopathology MH - Syndrome MH - Young Adult PMC - PMC3245800 MID - NIHMS337413 FIR - Cannon, Tyrone D IR - Cannon TD FIR - Addington, Jean IR - Addington J FIR - Cadenhead, Kristin IR - Cadenhead K FIR - Cornblatt, Barbara IR - Cornblatt B FIR - Heinssen, Robert IR - Heinssen R FIR - Mathalon, Daniel IR - Mathalon D FIR - McGlashan, Thomas IR - McGlashan T FIR - Perkins, Diana IR - Perkins D FIR - Rumsey, Judy IR - Rumsey J FIR - Seidman, Larry IR - Seidman L FIR - Tsuang, Ming IR - Tsuang M FIR - Walker, Elaine IR - Walker E FIR - Woods, Scott W IR - Woods SW FIR - Cannon, Tyrone D IR - Cannon TD FIR - Bearden, Carrie E IR - Bearden CE FIR - Jacobson, Sarah IR - Jacobson S FIR - Sun, Frank IR - Sun F FIR - Karlsgodt, Katherine IR - Karlsgodt K FIR - Gee, Dylan IR - Gee D FIR - Forsyth, Jennifer IR - Forsyth J FIR - Toga, Arthur IR - Toga A FIR - Thompson, Paul IR - Thompson P FIR - Bachman, Peter IR - Bachman P FIR - Zinberg, Jamie IR - Zinberg J FIR - De Silva, Sandra IR - De Silva S FIR - Andaya, Angela IR - Andaya A FIR - Roman, Cristina IR - Roman C FIR - McManus, Shauna IR - McManus S FIR - Marvin, Sarah IR - Marvin S FIR - Villodas, Miguel IR - Villodas M FIR - Ferng, Nichol IR - Ferng N FIR - Xu, Anna IR - Xu A FIR - Lau, Wendy IR - Lau W FIR - Walker, Elaine IR - Walker E FIR - Trotman, Hanan IR - Trotman H FIR - Hu, Xiaoping IR - Hu X FIR - Zhou, Lei IR - Zhou L FIR - Hamann, Stephan IR - Hamann S FIR - Ryan, Arthur IR - Ryan A FIR - Duncan, Erica IR - Duncan E FIR - Brasfield, Joy IR - Brasfield J FIR - Ryan, Arthur IR - Ryan A FIR - Pless, Anna IR - Pless A FIR - Perlow, Ben IR - Perlow B FIR - Shapiro, Dan IR - Shapiro D FIR - Goulding, Sandy IR - Goulding S FIR - Holtzman, Carrie IR - Holtzman C FIR - MacDonald, Allison IR - MacDonald A FIR - Ryan, Arthur IR - Ryan A FIR - Jones, Erin IR - Jones E FIR - Lui, David IR - Lui D FIR - Perlow, Ben IR - Perlow B FIR - Seidman, Larry IR - Seidman L FIR - Woodberry, Kristen IR - Woodberry K FIR - Giuliano, Anthony IR - Giuliano A FIR - Friedman-Yakoobian, Michelle IR - Friedman-Yakoobian M FIR - Stone, William IR - Stone W FIR - Thermenos, Heidi IR - Thermenos H FIR - Niznikiewicz, Margaret IR - Niznikiewicz M FIR - McCarley, Robert IR - McCarley R FIR - Tucker, Linda IR - Tucker L FIR - Pilo, Corin IR - Pilo C FIR - Picard, Maryan IR - Picard M FIR - Brent, Benjamin IR - Brent B FIR - Cousins, Ann IR - Cousins A FIR - Mesholam-Gately, Raquelle IR - Mesholam-Gately R FIR - Gnong Granato, Andrea IR - Gnong Granato A FIR - Rodenhiser-Hill, Janine IR - Rodenhiser-Hill J FIR - Wojcik, Joanne IR - Wojcik J FIR - Gibson, Lauren IR - Gibson L FIR - Juelich, Richard IR - Juelich R FIR - Kim, Danbee IR - Kim D FIR - Min, Grace IR - Min G FIR - Serur, Rachel IR - Serur R FIR - Yaffe, Beril IR - Yaffe B FIR - Cornblatt, Barbara IR - Cornblatt B FIR - Auther, Andrea IR - Auther A FIR - McLaughlin, Danielle IR - McLaughlin D FIR - Olvet, Doreen IR - Olvet D FIR - Kingsley, Peter IR - Kingsley P FIR - Carrion, Ricardo IR - Carrion R FIR - Brucato, Gary IR - Brucato G FIR - Olsen, Ruth IR - Olsen R FIR - Taylor, Tricia IR - Taylor T FIR - Barsky, Rita IR - Barsky R FIR - Snyder, Stephanie IR - Snyder S FIR - Farabaugh, Miranda IR - Farabaugh M FIR - Chang, Jeremy IR - Chang J FIR - Candan, Kristin IR - Candan K FIR - Perkins, Diana IR - Perkins D FIR - Penn, David IR - Penn D FIR - Belger, Ayse IR - Belger A FIR - Donkers, Franc IR - Donkers F FIR - Pelletier, Andrea IR - Pelletier A FIR - Graham, Karen IR - Graham K FIR - Landaas, Bryan IR - Landaas B FIR - Pelletier, Andrea IR - Pelletier A FIR - Rothman, Ellen IR - Rothman E FIR - Nieri, Jennifer IR - Nieri J FIR - Landaas, Bryan IR - Landaas B FIR - Lansing, Katie IR - Lansing K FIR - Pelletier, Andrea IR - Pelletier A FIR - Cadenhead, Kristin IR - Cadenhead K FIR - Heaton, Robert IR - Heaton R FIR - Brown, Greg IR - Brown G FIR - Mirzakhanian, Heline IR - Mirzakhanian H FIR - Light, Greg IR - Light G FIR - Alderman, Tracy IR - Alderman T FIR - Domingues, Isabel IR - Domingues I FIR - Haroun, Nasra IR - Haroun N FIR - Reding, Steve IR - Reding S FIR - Nunag, Jason IR - Nunag J FIR - Roman, Daniel IR - Roman D FIR - Robles, Clara IR - Robles C FIR - Addington, Jean IR - Addington J FIR - Kennedy, Jim IR - Kennedy J FIR - Frayne, Richard IR - Frayne R FIR - Goodyear, Brad IR - Goodyear B FIR - Raedler, Thomas IR - Raedler T FIR - Pillay, Neelan IR - Pillay N FIR - Stowkowy, Jacque IR - Stowkowy J FIR - Addington, Jack IR - Addington J FIR - Lui, Lu IR - Lui L FIR - Piskulic, Danijela IR - Piskulic D FIR - McGregor, Lisa IR - McGregor L FIR - Kumar, Angie IR - Kumar A FIR - Marshall, Catherine IR - Marshall C FIR - MacQuarrie, Nora IR - MacQuarrie N FIR - Smith, Kendra IR - Smith K FIR - Fitton, Emma IR - Fitton E FIR - Falukozi, Erin IR - Falukozi E FIR - Colijn, Mark IR - Colijn M FIR - Peterson, Aaron IR - Peterson A FIR - Sandu, Sona IR - Sandu S FIR - Legere, Lianne IR - Legere L FIR - Woods, Scott W IR - Woods SW FIR - McGlashan, Thomas H IR - McGlashan TH FIR - Hawkins, Keith A IR - Hawkins KA FIR - Qiu, Maolin IR - Qiu M FIR - Constable, R Todd IR - Constable RT FIR - Pearlson, Godfrey D IR - Pearlson GD FIR - Johannesen, Jason K IR - Johannesen JK FIR - Gunduz-Bruce, Handan IR - Gunduz-Bruce H FIR - Saksa, John R IR - Saksa JR FIR - Walsh, Barbara C IR - Walsh BC FIR - Popp-Santamauro, Nicole IR - Popp-Santamauro N FIR - Kenney, Joshua IR - Kenney J FIR - Roman, Brenton IR - Roman B FIR - Carlquist, Andrew IR - Carlquist A FIR - Mathalon, Daniel IR - Mathalon D FIR - Roach, Brian J IR - Roach BJ FIR - Miller, Ryan M IR - Miller RM FIR - Heinssen, Robert IR - Heinssen R FIR - Rumsey, Judy IR - Rumsey J EDAT- 2011/11/08 06:00 MHDA- 2012/04/18 06:00 PMCR- 2013/01/01 CRDT- 2011/11/08 06:00 PHST- 2011/04/23 00:00 [received] PHST- 2011/10/06 00:00 [revised] PHST- 2011/10/13 00:00 [accepted] PHST- 2011/11/08 06:00 [entrez] PHST- 2011/11/08 06:00 [pubmed] PHST- 2012/04/18 06:00 [medline] PHST- 2013/01/01 00:00 [pmc-release] AID - S0920-9964(11)00540-8 [pii] AID - 10.1016/j.schres.2011.10.005 [doi] PST - ppublish SO - Schizophr Res. 2012 Jan;134(1):1-9. doi: 10.1016/j.schres.2011.10.005. Epub 2011 Nov 6.