PMID- 22056283
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20120319
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 160
IP  - 4
DP  - 2012 Apr
TI  - Neonatal magnetic resonance imaging and outcome at age 30 months in extremely 
      preterm infants.
PG  - 559-566.e1
LID - 10.1016/j.jpeds.2011.09.053 [doi]
AB  - OBJECTIVE: To examine associations between brain white matter abnormalities, 
      including diffuse excessive high signal intensities, detected on neonatal 
      magnetic resonance imaging (MRI) with neurodevelopmental outcome at age 30 
      months. STUDY DESIGN: This was a prospective, population-based study of infants 
      born at <27 weeks gestation (n=117) undergoing conventional MRI at term 
      equivalent age (n=107). At age 30 months corrected, 91 of the preterm infants 
      (78%) and 85 term-born controls were assessed with the Bayley Scales of Infant 
      and Toddler Development, Third Edition (BSID-III). RESULTS: Cerebral palsy (CP) 
      was present in 7% of the preterm group. On the BSID-III, mean composite scores 
      were 96+/-9.5 for the cognitive scale, 97+/-14 for language scales, and 103+/-15 for 
      motor scales, all within the normal range for age. Compared with the term-born 
      controls, however, the preterm infants did not perform as well on all 3 scales, 
      also when MRI was normal. Significant associations were seen between moderate to 
      severe white matter abnormalities and CP (P<.001). The presence of diffuse 
      excessive high signal intensities was not associated with performance on the 
      BSID-III or with CP. CONCLUSION: This 3-year cohort of extremely preterm infants 
      had low rates of major brain injury and impaired outcome. Neonatal MRI provides 
      useful information, but this information needs to be treated with caution when 
      predicting outcome.
CI  - Copyright A(c) 2012 Mosby, Inc. All rights reserved.
FAU - Skiold, Beatrice
AU  - Skiold B
AD  - Department of Women's and Children's Health, Karolinska Institute, Stockholm, 
      Sweden. beatrice.skiold@karolinska.se
FAU - Vollmer, Brigitte
AU  - Vollmer B
FAU - Bohm, Birgitta
AU  - Bohm B
FAU - Hallberg, Boubou
AU  - Hallberg B
FAU - Horsch, Sandra
AU  - Horsch S
FAU - Mosskin, Mikael
AU  - Mosskin M
FAU - Lagercrantz, Hugo
AU  - Lagercrantz H
FAU - Aden, Ulrika
AU  - Aden U
FAU - Blennow, Mats
AU  - Blennow M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111104
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
CIN - J Pediatr. 2012 Apr;160(4):537-8. PMID: 22188782
MH  - Brain Diseases/*diagnosis
MH  - Developmental Disabilities/*diagnosis
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Premature, Diseases/*diagnosis
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Prospective Studies
EDAT- 2011/11/08 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/03/30 00:00 [received]
PHST- 2011/08/08 00:00 [revised]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - S0022-3476(11)01007-9 [pii]
AID - 10.1016/j.jpeds.2011.09.053 [doi]
PST - ppublish
SO  - J Pediatr. 2012 Apr;160(4):559-566.e1. doi: 10.1016/j.jpeds.2011.09.053. Epub 
      2011 Nov 4.