PMID- 22056847
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20120113
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 163
IP  - 1
DP  - 2012 Jan
TI  - The influence of HLA alleles and HBV subgenotyes on the outcomes of HBV 
      infections in Northeast China.
PG  - 328-33
LID - 10.1016/j.virusres.2011.10.020 [doi]
AB  - Hepatitis B virus (HBV) infection has a wide variety of clinical outcomes, it 
      could be spontaneouly recovered and also could develop fulminant liver failure or 
      cirrhosis with hepatocellular carcinoma. Human leukocyte antigen (HLA) 
      polymorphism and HBV (sub)genotypes have been speculated to associate with the 
      outcome of HBV infection because the data obtained from various populations who 
      bear different HLA alleles have shown a HLA polymorphism associated outcome of 
      HBV infection. However, as the most important viral and host genetic factors, the 
      impact of HBV (sub)genotypes in combination with HLA polymorphism on the clinical 
      outcomes of HBV infections remains unclear. To demonstrate the association of HLA 
      allele polymorphism in combination with HBV subgenotypes with the outcome of HBV 
      infection in Northeastern Han Chinese population, a total of 230 HBV-infected 
      individuals (Infection group) were compared to 210 random selected controls 
      (Control group) who are negative for HBV infection for their HLA alleles 
      frequency as well as the associations with the virus infection, clearance and 
      persistence in combination with HBV subgenotypes. Of the 230 HBV-infected 
      subjects, 54 were acute self-limited hepatitis (ASH) with HBV subgenotype C2 
      (ASH-C2), 144 were chronic hepatitis (CH) with HBV subgenotype C2 and B2 (CH-C2 
      and CH-B2), and 32 were spontaneously recovered (SR) without subgenotype results. 
      When two groups are compared, the results suggest that B*48, B*51 and DRB1*12 
      carrier may have a high risk for HBV infection, but B*51 is likely association 
      with spontaneous recovery and DRB1*07, 12 may be implied in viral persistence. 
      HLA-B*15, DRB1*11 and 14 associated with viral clearance in the cases of HBV-C2 
      infection; HLA-B*54 carriers in chronic group are more sensitive to with the 
      infection of HBV subgenotype B2; HLA-B*07 and DRB1*13 may protect subjects from 
      HBV infection. The data presented a link between HLA polymorphism and HBV 
      pathogenesis and suggested potential therapeutic targets for hepatitis B.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Li, Xingku
AU  - Li X
AD  - Research Center of the Second Affiliated Hospital of Harbin Medical University, 
      Harbin, People's Republic of China.
FAU - Liu, Wei
AU  - Liu W
FAU - Wang, Hongyan
AU  - Wang H
FAU - Jin, Xi
AU  - Jin X
FAU - Fang, Shaohong
AU  - Fang S
FAU - Shi, Yuguang
AU  - Shi Y
FAU - Liu, Zhen
AU  - Liu Z
FAU - Zhang, Shuyun
AU  - Zhang S
FAU - Yang, Shufen
AU  - Yang S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111025
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Hepatitis B/*genetics/immunology/virology
MH  - Hepatitis B virus/classification/genetics/*immunology/*pathogenicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
EDAT- 2011/11/08 06:00
MHDA- 2012/05/05 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/06/02 00:00 [received]
PHST- 2011/10/15 00:00 [revised]
PHST- 2011/10/20 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
AID - S0168-1702(11)00414-X [pii]
AID - 10.1016/j.virusres.2011.10.020 [doi]
PST - ppublish
SO  - Virus Res. 2012 Jan;163(1):328-33. doi: 10.1016/j.virusres.2011.10.020. Epub 2011 
      Oct 25.