PMID- 22057034
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20151119
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 208
IP  - 2
DP  - 2012 Jan 25
TI  - Developmental stage-specific changes in immunological biomarkers in male C3H/HeN 
      mice after early life toluene exposure.
PG  - 133-41
LID - 10.1016/j.toxlet.2011.10.015 [doi]
AB  - We investigated the effects of low-level toluene exposure on immunological 
      biomarkers during different developmental stages in infant mice. Fetuses in utero 
      in the pregnant mice on gestational day (GD) 14 as well as male pups on postnatal 
      day (PND) 2 and PND 8 were exposed either to filtered air (control; 0 ppm), or to 
      5 ppm or to 50 ppm of toluene for 5 consecutive days in the whole body exposure 
      chamber. Immunological biomarkers in the blood and spleen of PND 21 male mice 
      were examined by ELISA, real-time RT-PCR, flow cytometry, and histological 
      analysis. Plasma total IgG1 levels were markedly reduced in PND 21 mice exposed 
      to 5 ppm of toluene during all developmental stages. Splenic T lymphocyte subsets 
      and mRNA expression levels of Th1 cytokine IL-12, transcription factor T-bet, and 
      Foxp3 were significantly suppressed in PND 21 male mice exposed to toluene during 
      PNDs 8-12. There were changes in some immunological biomarkers in PND 42 mice 
      exposed to toluene during PNDs 8-12. These findings indicate developmental 
      stage-specific changes in non-specific immunological biomarkers in mice after 
      early life toluene exposure.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Win-Shwe, Tin-Tin
AU  - Win-Shwe TT
AD  - National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 
      305-8506, Japan.
FAU - Kunugita, Naoki
AU  - Kunugita N
FAU - Nakajima, Daisuke
AU  - Nakajima D
FAU - Yoshida, Yasuhiro
AU  - Yoshida Y
FAU - Fujimaki, Hidekazu
AU  - Fujimaki H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111025
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Biomarkers)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Immunoglobulin G)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
RN  - 187348-17-0 (Interleukin-12)
RN  - 3FPU23BG52 (Toluene)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/immunology
MH  - Biomarkers
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Forkhead Transcription Factors/blood
MH  - Immunity, Cellular/*drug effects
MH  - Immunity, Humoral/*drug effects
MH  - Immunoglobulin G/blood
MH  - Interleukin-12/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/immunology
MH  - Real-Time Polymerase Chain Reaction
MH  - T-Box Domain Proteins/blood
MH  - T-Lymphocyte Subsets/drug effects
MH  - T-Lymphocytes/drug effects
MH  - Toluene/*toxicity
EDAT- 2011/11/08 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/08/22 00:00 [received]
PHST- 2011/10/18 00:00 [revised]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - S0378-4274(11)01582-7 [pii]
AID - 10.1016/j.toxlet.2011.10.015 [doi]
PST - ppublish
SO  - Toxicol Lett. 2012 Jan 25;208(2):133-41. doi: 10.1016/j.toxlet.2011.10.015. Epub 
      2011 Oct 25.