PMID- 22057119
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20171116
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 37
IP  - 1
DP  - 2012 May
TI  - Cloning and expression analysis of the transforming growth factor-beta receptors 
      type 1 and 2 in the rainbow trout Oncorhynchus mykiss.
PG  - 115-26
LID - 10.1016/j.dci.2011.10.006 [doi]
AB  - Transforming growth factor-beta (TGF-beta) binding to the TGF-beta type I (TGFBR1) and 
      type II (TGFBR2) receptors delivers a plethora of cell-type specific effects. 
      Moreover, the responses to TGF-beta are tuned by regulatory mechanisms at the 
      receptor level itself. To further elucidate TGF-beta family signal transduction in 
      teleosts, we therefore cloned the first complete set of a putative TGF-beta receptor 
      complex in salmonids. Rainbow trout TGFBR1 and TGFBR2 are transmembrane proteins 
      with a serine/threonine kinase domain and are highly conserved within 
      vertebrates. High expression levels in muscle and brain indicate regulation of 
      the TGF-beta system in muscular and nervous systems. Lipopolysaccharide (LPS) 
      induced expression of both receptor chains in RTgill cells while bacterial and 
      viral mimics modulated the two receptors inversely in head kidney (HK) 
      macrophages. In addition, T cell mitogens lowered receptor levels in HK 
      leukocytes. These data provide the first insights into TGF-beta type I and II 
      receptor modulation during immune responses in teleost fish.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Maehr, Tanja
AU  - Maehr T
AD  - Scottish Fish Immunology Research Centre, Institute of Biological and 
      Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK.
FAU - Wang, Tiehui
AU  - Wang T
FAU - Gonzalez Vecino, Jose L
AU  - Gonzalez Vecino JL
FAU - Wadsworth, Simon
AU  - Wadsworth S
FAU - Secombes, Christopher J
AU  - Secombes CJ
LA  - eng
SI  - GENBANK/FN822751
SI  - GENBANK/FN822752
PT  - Journal Article
DEP - 20111023
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Interferon Inducers)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, Transforming Growth Factor beta)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/metabolism
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - *Gene Expression
MH  - Gene Expression Regulation
MH  - Head Kidney/cytology
MH  - Interferon Inducers/pharmacology
MH  - Leukocytes/immunology/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophages/immunology/metabolism
MH  - Molecular Sequence Data
MH  - Muscles/metabolism
MH  - Oncorhynchus mykiss/*genetics/immunology/metabolism
MH  - Organ Specificity
MH  - Phylogeny
MH  - Poly I-C/pharmacology
MH  - Receptors, Transforming Growth Factor beta/*genetics/metabolism
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
EDAT- 2011/11/08 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/09/09 00:00 [received]
PHST- 2011/10/07 00:00 [revised]
PHST- 2011/10/09 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - S0145-305X(11)00279-5 [pii]
AID - 10.1016/j.dci.2011.10.006 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2012 May;37(1):115-26. doi: 10.1016/j.dci.2011.10.006. Epub 
      2011 Oct 23.