PMID- 22058062
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20211021
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Feb
TI  - Identification of human herpesviruses 1 to 8 in Tunisian multiple sclerosis 
      patients and healthy blood donors.
PG  - 12-9
LID - 10.1007/s13365-011-0056-z [doi]
AB  - Members of the human Herpesviridae family are candidates for representing the 
      macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis. 
      To verify the possible role of human herpesviruses (HHVs) as triggering or 
      aggravating factors in relapsing-remitting multiple sclerosis clinical outcome, 
      we studied the prevalence of all eight human herpesviruses in whole blood samples 
      collected from 51 MS patients and from 51 healthy controls. The presence of DNA 
      of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), varicella zoster virus 
      (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus 
      6 (HHV-6), human herpesvirus 7 (HHV-7) and human herpesvirus 8 (HHV-8) was 
      searched by specific nested polymerase chain reaction. HHVs were significantly 
      more prevalent in the blood of MS patients than in those of the controls 
      (P < 10(-4)). HSV-1, HSV-2, HCMV and HHV-8 were negative in both MS patients and 
      controls samples. In MS patients, EBV, HHV-7, HHV-6 and VZV were detected in 
      31.3%, 33.3%, 5.8% and 7.8% of samples, respectively, compared with 3.9%, 9.8%, 
      1.96% and 1.96%, respectively, of samples from controls. We found a statistically 
      significant difference only for EBV DNA and for HHV-7 DNA prevalence (P < 0.001 
      and P = 0.03). Although these results indicate lack of apparent association in 
      terms of gender, type of diagnosis, symptoms, disease score and beta interferon 
      treatment between EBV or HHV-7 to MS among Tunisian patients, heterogeneity 
      related to genetic polymorphism as well as geographical distribution of the 
      disease and of pathogens may be of significance.
FAU - Ben Fredj, Nadia
AU  - Ben Fredj N
AD  - Laboratory of Transmissible Diseases and Biological Active substances, LR99-ES27, 
      Faculty of Pharmacy, University of Monastir, Avicenne street 5000, Monastir, 
      Tunisia. benfredj_nadia@yahoo.fr
FAU - Rotola, Antonella
AU  - Rotola A
FAU - Nefzi, Faten
AU  - Nefzi F
FAU - Chebel, Saber
AU  - Chebel S
FAU - Rizzo, Roberta
AU  - Rizzo R
FAU - Caselli, Elisabetta
AU  - Caselli E
FAU - Frih-Ayed, Mahbouba
AU  - Frih-Ayed M
FAU - Di Luca, Dario
AU  - Di Luca D
FAU - Aouni, Mahjoub
AU  - Aouni M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111105
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - DNA, Viral/*analysis/biosynthesis
MH  - Epstein-Barr Virus Infections/diagnosis/epidemiology/virology
MH  - Female
MH  - Herpes Simplex/diagnosis/epidemiology/virology
MH  - Herpesvirus 4, Human/genetics/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/epidemiology/*virology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Prevalence
MH  - Roseolovirus/genetics/*isolation & purification
MH  - Roseolovirus Infections/diagnosis/epidemiology/virology
MH  - Simplexvirus/genetics/*isolation & purification
MH  - Tunisia/epidemiology
EDAT- 2011/11/08 06:00
MHDA- 2013/06/20 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/08/01 00:00 [received]
PHST- 2011/09/28 00:00 [accepted]
PHST- 2011/09/19 00:00 [revised]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - 10.1007/s13365-011-0056-z [doi]
PST - ppublish
SO  - J Neurovirol. 2012 Feb;18(1):12-9. doi: 10.1007/s13365-011-0056-z. Epub 2011 Nov 
      5.