PMID- 22058335
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20211021
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 52
IP  - 13
DP  - 2011 Dec 9
TI  - Effect of acute intraocular pressure elevation on the monkey optic nerve head as 
      detected by spectral domain optical coherence tomography.
PG  - 9431-7
LID - 10.1167/iovs.11-7922 [doi]
AB  - PURPOSE: To determine whether acutely elevated IOP alters optic nerve head (ONH) 
      structural parameters characterized in vivo using spectral domain optical 
      coherence tomography (SD-OCT). METHODS: Five rhesus macaques were tested under 
      isoflurane anesthesia. SD-OCT images of the ONH of both eyes were acquired 30 
      minutes after IOP was stabilized to 10 mm Hg and 60 minutes after stabilization 
      to 45 mm Hg. The internal limiting membrane, Bruch's membrane/retinal pigment 
      epithelium, neural canal opening (NCO), and anterior lamina cribrosa surface 
      (ALCS) were delineated using custom software. Differences in SD-OCT structural 
      parameters between the two IOP levels were assessed using generalized estimating 
      equations. In six eyes of three animals, images were acquired after 10 minutes 
      and 30 minutes of IOP stabilization to 10 mm Hg (control experiment). RESULTS: 
      Acute IOP elevation resulted in a reduction in prelaminar tissue thickness (mean, 
      -47 mum; SD, 25 mum; P = 0.002), rim volume (-0.05 mm(3), 0.02 mm(3); P = 0.002), 
      rim width (-30 mum, 7 mum; P = 0.002), and in an increase in NCO depth (38 mum, 15 
      mum; P = 0.002). An increase in ALCS depth was significant relative to peripheral 
      Bruch's membrane (48 mum, 24 mum; P = 0.002) but not relative to the NCO. No 
      significant parameter changes were detected in the control eyes. CONCLUSIONS: 
      Surface compliance changes in the normal monkey ONH primarily reflect prelaminar 
      and peripapillary deformation. SD-OCT compliance testing will further our 
      understanding of the effects of IOP on the ONH and help improve and validate 
      numerical models of ONH biomechanics.
FAU - Strouthidis, Nicholas G
AU  - Strouthidis NG
AD  - Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health, 
      Portland, Oregon 97208-3950, USA.
FAU - Fortune, Brad
AU  - Fortune B
FAU - Yang, Hongli
AU  - Yang H
FAU - Sigal, Ian A
AU  - Sigal IA
FAU - Burgoyne, Claude F
AU  - Burgoyne CF
LA  - eng
GR  - R01 EY011610/EY/NEI NIH HHS/United States
GR  - R01-EY11610/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111209
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Follow-Up Studies
MH  - Intraocular Pressure/*physiology
MH  - Macaca mulatta
MH  - Ocular Hypertension/complications/*pathology/physiopathology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/etiology/*pathology/physiopathology
MH  - Tomography, Optical Coherence/*methods
PMC - PMC3293414
EDAT- 2011/11/08 06:00
MHDA- 2012/02/01 06:00
PMCR- 2012/06/01
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - iovs.11-7922 [pii]
AID - 11-7922 [pii]
AID - 10.1167/iovs.11-7922 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2011 Dec 9;52(13):9431-7. doi: 10.1167/iovs.11-7922.