PMID- 22059094
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240320
IS  - 1757-1006 (Print)
IS  - 1757-1014 (Electronic)
IS  - 1757-1006 (Linking)
VI  - 3
IP  - 1
DP  - 2009
TI  - Testing for Rheumatological Diagnoses in Children.
PG  - 30-34
AB  - Paediatricians often order laboratory and radiological tests to identify children 
      with potential rheumatological disease prior to subspeciality referral. However, 
      the pattern of testing suggests inadequate understanding of their diagnostic 
      utility and limitations. Herein we will address some of the most common 
      rheumatological diagnoses encountered in the subspeciality clinic - juvenile 
      idiopathic arthritis (JIA), juvenile spondyloarthritis (JSpA) and systemic lupus 
      erythematosus (SLE), and related connective tissue diseases - and the tests most 
      frequently ordered to diagnose them: anti-nuclear antibodies (ANA), rheumatoid 
      factor (RF), human leukocyte antigen (HLA)-B27 and radiological tests. This 
      article will highlight the sensitivity, specificity and positive predictive value 
      of the tests. In general, none of these tests were appropriate to use as 
      rheumatological 'screens', as no individual test was diagnostic. Specific tests 
      should be ordered only when there is a high clinical index of suspicion for a 
      particular disease entity. Greater understanding of a test's diagnostic utility 
      should decrease unnecessary testing, anxiety and expense and aid in 
      interpretation.
FAU - Smith, Judith A
AU  - Smith JA
AD  - University of Wisconsin-Madison School of Medicine and Public Health, Department 
      of Pediatrics.
LA  - eng
GR  - UL1 RR025011-03/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-02/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-05/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-01/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-04/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Eur Paediatr Rev
JT  - European paediatrics review
JID - 101552455
PMC - PMC3207318
MID - NIHMS261359
COIS- Disclosure: The author has no conflicts of interest to declare.
EDAT- 2009/01/01 00:00
MHDA- 2009/01/01 00:01
PMCR- 2011/11/03
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2009/01/01 00:01 [medline]
PHST- 2011/11/03 00:00 [pmc-release]
PST - ppublish
SO  - Eur Paediatr Rev. 2009;3(1):30-34.