PMID- 22065279
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20211021
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Linking)
VI  - 31
IP  - 7
DP  - 2012 Jul
TI  - H1N1v at a seroepidemiological glance: is the nightmare over?
PG  - 1467-71
LID - 10.1007/s10096-011-1465-x [doi]
AB  - When the second wave of pandemic influenza A H1N1v 2009 (H1N1v) emerged in the 
      winter of 2010/2011, public health authorities were afraid of dangerous 
      implications and severe clinical courses again. As further H1N1v waves might 
      appear, achievement of sufficient herd immunity is a matter of urgency. The 
      objective of this study was to determine the seroprevalence of antibodies against 
      H1N1v by hemagglutination-inhibition test (HI) after the second wave. We compared 
      our recent findings with our data obtained after the first pandemic in 2009/2010. 
      Between March and May 2011 we collected serum samples from 600 persons aged 1 to 
      84 years admitted to University Hospital Frankfurt/Main and analysed the titres 
      of anti-H1N1v by HI. The overall seroprevalence of anti-H1N1v has risen from 
      36.9% (95% confidence interval (95%CI), 33-41) in unvaccinated persons after the 
      first wave to 57.3% (95%CI, 53.1-61.2) in vaccinated and unvaccinated. The 
      highest rate of seropositivity was detected in the age group of 10-19 years (66%; 
      95%CI, 55.8-75.2), whereas the lowest was found in the age group 40-59 years 
      (51%; 95%CI, 40.8-61.1). Although seroprevalence has significantly increased, 
      sufficient herd immunity is still not achieved. Therefore, general vaccination 
      programs have to be propagated continuously by public health authorities.
FAU - Reinheimer, C
AU  - Reinheimer C
AD  - Institute for Medical Virology, University Hospital Frankfurt am Main, 
      Paul-Ehrlich-Strasse 40, 60596, Frankfurt am Main, Germany. 
      claudia.reinheimer@kgu.de
FAU - Doerr, H W
AU  - Doerr HW
FAU - Friedrichs, I
AU  - Friedrichs I
FAU - Sturmer, M
AU  - Sturmer M
FAU - Allwinn, R
AU  - Allwinn R
LA  - eng
PT  - Journal Article
DEP - 20111109
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Viral/*blood
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Germany/epidemiology
MH  - Hemagglutination Inhibition Tests
MH  - Humans
MH  - Immunity, Herd
MH  - Infant
MH  - Influenza A Virus, H1N1 Subtype/*classification/immunology/*isolation & 
      purification
MH  - Influenza, Human/*epidemiology/immunology/*virology
MH  - Male
MH  - Middle Aged
MH  - Seroepidemiologic Studies
MH  - Young Adult
EDAT- 2011/11/09 06:00
MHDA- 2012/08/31 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/06/06 00:00 [received]
PHST- 2011/10/01 00:00 [accepted]
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - 10.1007/s10096-011-1465-x [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1467-71. doi: 
      10.1007/s10096-011-1465-x. Epub 2011 Nov 9.