PMID- 22065918
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20221207
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 17
DP  - 2011
TI  - CFH 184G as a genetic risk marker for anterior uveitis in Chinese females.
PG  - 2655-64
AB  - OBJECTIVE: To investigate the association of three single nucleotide 
      polymorphisms (SNPs) in the complement factor H (CFH), KIAA1109, and 
      interleukin-27 (IL-27) genes in patients with anterior uveitis (AU). METHODS: A 
      case-control study was performed in 98 Chinese AU patients and 308 healthy 
      controls. Three SNPs including CFH-rs800292, KIAA1109-rs4505848, and 
      IL27-rs4788084 were detected using TaqMan SNP Genotyping Assays. Analyses were 
      also stratified according to gender, clinical features and human leukocyte 
      antigen (HLA)-B27 status of the patients. RESULTS: No significant association was 
      found between all three SNPs and AU. However, when stratified by gender, there 
      were significant increases in the frequency of the CFH-rs800292 184G allele and 
      GG homozygosity in female patients compared with control subjects (p=0.003 and 
      p=0.009, respectively). Similar association was not detected in males. No 
      significant association was found between AU and KIAA1109-rs4505848 or 
      IL27-rs4788084 even stratified by gender. There was no significant difference in 
      genotypes of AU patients stratified by various clinical features. Subgroup 
      analyses showed that all three SNPs (rs800292, rs4505848, and rs4788084) were not 
      associated with AU in HLA-B27-positive patients, neither in HLA-B27-negative 
      patients. CONCLUSIONS: Our results showed an association between AU and CFH 
      polymorphism in Chinese female patients but not in males, indicating 
      gender-specific genetic differences in CFH. Gender should be considered in 
      genetic studies of anterior uveitis even extending to other immunologic diseases.
FAU - Yang, Ming-ming
AU  - Yang MM
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, China.
FAU - Lai, Timothy Y Y
AU  - Lai TY
FAU - Tam, Pancy O S
AU  - Tam PO
FAU - Chiang, Sylvia W Y
AU  - Chiang SW
FAU - Chan, Carmen K M
AU  - Chan CK
FAU - Luk, Fiona O J
AU  - Luk FO
FAU - Ng, Tsz Kin
AU  - Ng TK
FAU - Pang, Chi-Pui
AU  - Pang CP
LA  - eng
PT  - Journal Article
DEP - 20111013
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (CFH protein, human)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Interleukin-17)
RN  - 0 (Nuclear Proteins)
RN  - 80295-65-4 (Complement Factor H)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Complement Factor H/genetics
MH  - DNA Fingerprinting
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genotype
MH  - HLA-B27 Antigen/genetics
MH  - Humans
MH  - Interleukin-17/*genetics
MH  - Middle Aged
MH  - Nuclear Proteins/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Sex Factors
MH  - Uveitis, Anterior/*genetics
PMC - PMC3209418
EDAT- 2011/11/09 06:00
MHDA- 2012/03/01 06:00
PMCR- 2011/01/01
CRDT- 2011/11/09 06:00
PHST- 2011/08/02 00:00 [received]
PHST- 2011/09/29 00:00 [accepted]
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 287 [pii]
AID - 2011MOLVIS0337 [pii]
PST - ppublish
SO  - Mol Vis. 2011;17:2655-64. Epub 2011 Oct 13.