PMID- 22066590
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20211021
IS  - 1526-4602 (Electronic)
IS  - 1525-7797 (Print)
IS  - 1525-7797 (Linking)
VI  - 13
IP  - 1
DP  - 2012 Jan 9
TI  - Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.
PG  - 12-22
LID - 10.1021/bm201143c [doi]
AB  - An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs 
      during the remodeling of tissue microenvironments following injury and during 
      disease processes such as cancer. We hypothesized that multimodality HA-based 
      probes selectively target and detectably accumulate at sites of high HA 
      metabolism, thus providing a flexible imaging strategy for monitoring disease and 
      repair processes. Kinetic analyses confirmed favorable available serum levels of 
      the probe following intravenous (i.v.) or subcutaneous (s.c.) injection. Nuclear 
      (technetium-HA, (99m)Tc-HA, and iodine-HA, (125)I-HA), optical (fluorescent Texas 
      Red-HA, TR-HA), and magnetic resonance (gadolinium-HA, Gd-HA) probes imaged liver 
      ((99m)Tc-HA), breast cancer cells/xenografts (TR-HA, Gd-HA), and vascular injury 
      ((125)I-HA, TR-HA). Targeting of HA probes to these sites appeared to result from 
      selective HA receptor-dependent localization. Our results suggest that HA-based 
      probes, which do not require polysaccharide backbone modification to achieve 
      favorable half-life and distribution, can detect elevated HA metabolism in 
      homeostatic, injured, and diseased tissues.
FAU - Veiseh, Mandana
AU  - Veiseh M
AD  - Division of Life Sciences, Lawrence Berkeley National Laboratories, Berkeley, 
      California, USA.
FAU - Breadner, Daniel
AU  - Breadner D
FAU - Ma, Jenny
AU  - Ma J
FAU - Akentieva, Natalia
AU  - Akentieva N
FAU - Savani, Rashmin C
AU  - Savani RC
FAU - Harrison, Rene
AU  - Harrison R
FAU - Mikilus, David
AU  - Mikilus D
FAU - Collis, Lisa
AU  - Collis L
FAU - Gustafson, Stefan
AU  - Gustafson S
FAU - Lee, Ting-Yim
AU  - Lee TY
FAU - Koropatnick, James
AU  - Koropatnick J
FAU - Luyt, Leonard G
AU  - Luyt LG
FAU - Bissell, Mina J
AU  - Bissell MJ
FAU - Turley, Eva A
AU  - Turley EA
LA  - eng
GR  - R01 HL062472/HL/NHLBI NIH HHS/United States
GR  - MOP82720/CAPMC/CIHR/Canada
GR  - R37 CA064786/CA/NCI NIH HHS/United States
GR  - U54 CA143836/CA/NCI NIH HHS/United States
GR  - U54CA143836/CA/NCI NIH HHS/United States
GR  - R37CA064786/CA/NCI NIH HHS/United States
GR  - F32 CA132491/CA/NCI NIH HHS/United States
GR  - U54 CA112970/CA/NCI NIH HHS/United States
GR  - U01CA143233/CA/NCI NIH HHS/United States
GR  - R01 CA057621/CA/NCI NIH HHS/United States
GR  - R01CA057621/CA/NCI NIH HHS/United States
GR  - U01 CA143233/CA/NCI NIH HHS/United States
GR  - FCA132491A/PHS HHS/United States
GR  - U54CA126552/CA/NCI NIH HHS/United States
GR  - U54CA112970/CA/NCI NIH HHS/United States
GR  - R01 HL075930/HL/NHLBI NIH HHS/United States
GR  - U54 CA126552/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111212
PL  - United States
TA  - Biomacromolecules
JT  - Biomacromolecules
JID - 100892849
RN  - 0 (Molecular Probes)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/chemistry/*metabolism
MH  - *Liver Neoplasms, Experimental/metabolism/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - *Mammary Neoplasms, Experimental/metabolism/pathology
MH  - Mice
MH  - *Molecular Probes/chemistry/pharmacology
MH  - Neoplasm Transplantation
MH  - Rats
MH  - Rats, Nude
MH  - Tomography, Optical/*methods
MH  - Transplantation, Heterologous
MH  - Tumor Microenvironment
MH  - *Vascular Diseases/metabolism/pathology
PMC - PMC3658319
MID - NIHMS466638
EDAT- 2011/11/10 06:00
MHDA- 2012/04/25 06:00
PMCR- 2013/05/20
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
PHST- 2013/05/20 00:00 [pmc-release]
AID - 10.1021/bm201143c [doi]
PST - ppublish
SO  - Biomacromolecules. 2012 Jan 9;13(1):12-22. doi: 10.1021/bm201143c. Epub 2011 Dec 
      12.