PMID- 22068802
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20191120
IS  - 1806-4841 (Electronic)
IS  - 0365-0596 (Linking)
VI  - 86
IP  - 4 Suppl 1
DP  - 2011 Jul-Aug
TI  - Histoplasmosis-associated immune reconstitution inflammatory syndrome.
PG  - S168-72
LID - S0365-05962011000700044 [pii]
AB  - A 27-year-old HIV-positive male patient with disseminated cutaneous 
      histoplasmosis was treated with both HAART and amphotericin B (total accumulated 
      dose of 0.5 g). Amphotericin B was later replaced with itraconazole (200mg/day). 
      Two months after therapy had been started and the cutaneous lesions had healed, 
      the patient interrupted both treatments voluntarily and his health deteriorated. 
      HAART was then re-introduced and CD4+ cell count increased sharply at the same 
      time as lymph node histoplasmosis was diagnosed. This paradoxical response? the 
      relapse of histoplasmosis and concomitant increase in CD4+ cell count and 
      undetectable viral load after resumption of HAART ? suggests that this was a case 
      of immune reconstitution inflammatory syndrome (IRIS).
FAU - Passos, Leny
AU  - Passos L
AD  - Fundacao de Hematologia e Hemoterapia do Amazonas, Manaus, AM, Brasil.
FAU - Talhari, Carolina
AU  - Talhari C
FAU - Santos, Monica
AU  - Santos M
FAU - Ribeiro-Rodrigues, Rodrigo
AU  - Ribeiro-Rodrigues R
FAU - Ferreira, Luiz Carlos de Lima
AU  - Ferreira LC
FAU - Talhari, Sinesio
AU  - Talhari S
LA  - eng
LA  - por
PT  - Case Reports
PT  - Journal Article
PL  - Spain
TA  - An Bras Dermatol
JT  - Anais brasileiros de dermatologia
JID - 0067662
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications/immunology
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - CD4 Lymphocyte Count
MH  - Histoplasmosis/*complications/immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications/immunology
MH  - Male
MH  - Medication Adherence
MH  - Viral Load
EDAT- 2011/12/16 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/11/10 06:00
PHST- 2010/11/05 00:00 [received]
PHST- 2010/11/25 00:00 [accepted]
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - S0365-05962011000700044 [pii]
AID - 10.1590/s0365-05962011000700044 [doi]
PST - ppublish
SO  - An Bras Dermatol. 2011 Jul-Aug;86(4 Suppl 1):S168-72. doi: 
      10.1590/s0365-05962011000700044.