PMID- 22068868
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20160726
IS  - 1524-4563 (Electronic)
IS  - 0194-911X (Linking)
VI  - 59
IP  - 1
DP  - 2012 Jan
TI  - Caloric restriction ameliorates angiotensin II-induced mitochondrial remodeling 
      and cardiac hypertrophy.
PG  - 76-84
LID - 10.1161/HYPERTENSIONAHA.111.179457 [doi]
AB  - Angiotensin II-induced cardiac damage is associated with oxidative 
      stress-dependent mitochondrial dysfunction. Caloric restriction (CR), a dietary 
      regimen that increases mitochondrial activity and cellular stress resistance, 
      could provide protection. We tested that hypothesis in double transgenic rats 
      harboring human renin and angiotensinogen genes (dTGRs). CR (60% of energy intake 
      for 4 weeks) decreased mortality in dTGRs. CR ameliorated angiotensin II-induced 
      cardiomyocyte hypertrophy, vascular inflammation, cardiac damage and fibrosis, 
      cardiomyocyte apoptosis, and cardiac atrial natriuretic peptide mRNA 
      overexpression. The effects were blood pressure independent and were linked to 
      increased endoplasmic reticulum stress, autophagy, serum adiponectin level, and 
      5' AMP-activated protein kinase phosphorylation. CR decreased cardiac p38 
      phosphorylation, nitrotyrosine expression, and serum insulin-like growth factor 1 
      levels. Mitochondria from dTGR hearts showed clustered mitochondrial patterns, 
      decreased numbers, and volume fractions but increased trans-sectional areas. All 
      of these effects were reduced in CR dTGRs. Mitochondrial proteomic profiling 
      identified 43 dTGR proteins and 42 Sprague-Dawley proteins, of which 29 proteins 
      were in common in response to CR. We identified 7 proteins in CR dTGRs that were 
      not found in control dTGRs. In contrast, 6 mitochondrial proteins were identified 
      from dTGRs that were not detected in any other group. Gene ontology annotations 
      with the Panther protein classification system revealed downregulation of 
      cytoskeletal proteins and enzyme modulators and upregulation of oxidoreductase 
      activity in dTGRs. CR provides powerful, blood pressure-independent, protection 
      against angiotensin II-induced mitochondrial remodeling and cardiac hypertrophy. 
      The findings support the notion of modulating cardiac bioenergetics to ameliorate 
      angiotensin II-induced cardiovascular complications.
FAU - Finckenberg, Piet
AU  - Finckenberg P
AD  - Institute of Biomedicine, PO Box 63, University of Helsinki, Helsinki FI-00014, 
      Finland.
FAU - Eriksson, Ove
AU  - Eriksson O
FAU - Baumann, Marc
AU  - Baumann M
FAU - Merasto, Saara
AU  - Merasto S
FAU - Lalowski, Maciej M
AU  - Lalowski MM
FAU - Levijoki, Jouko
AU  - Levijoki J
FAU - Haasio, Kristiina
AU  - Haasio K
FAU - Kyto, Ville
AU  - Kyto V
FAU - Muller, Dominik N
AU  - Muller DN
FAU - Luft, Friedrich C
AU  - Luft FC
FAU - Oresic, Matej
AU  - Oresic M
FAU - Mervaala, Eero
AU  - Mervaala E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111107
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Proteome)
RN  - 0 (Vasoconstrictor Agents)
RN  - 11002-13-4 (Angiotensinogen)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Angiotensin II/*metabolism/pharmacology
MH  - Angiotensinogen/genetics
MH  - Animals
MH  - Apoptosis/physiology
MH  - Autophagy/drug effects/physiology
MH  - Blood Pressure/drug effects/physiology
MH  - Body Temperature/drug effects/physiology
MH  - Caloric Restriction/*methods
MH  - Cardiomegaly/*diet therapy/genetics/*metabolism
MH  - Endoplasmic Reticulum Stress/drug effects/physiology
MH  - Energy Metabolism/drug effects/physiology
MH  - Heart Rate/drug effects/physiology
MH  - Humans
MH  - Mitochondria/drug effects/*metabolism
MH  - Mitochondrial Diseases/metabolism/pathology
MH  - Myocytes, Cardiac/metabolism/pathology
MH  - Oxidative Stress/drug effects/physiology
MH  - Proteome/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rats, Transgenic
MH  - Renin/genetics
MH  - Survival Rate
MH  - Vasoconstrictor Agents/metabolism/pharmacology
EDAT- 2011/11/10 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - HYPERTENSIONAHA.111.179457 [pii]
AID - 10.1161/HYPERTENSIONAHA.111.179457 [doi]
PST - ppublish
SO  - Hypertension. 2012 Jan;59(1):76-84. doi: 10.1161/HYPERTENSIONAHA.111.179457. Epub 
      2011 Nov 7.