PMID- 22069078
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20120215
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 35
IP  - 3
DP  - 2012 Mar
TI  - Modulatory effects of acupuncture on resting-state networks: a functional MRI 
      study combining independent component analysis and multivariate Granger causality 
      analysis.
PG  - 572-81
LID - 10.1002/jmri.22887 [doi]
AB  - PURPOSE: To investigate acupuncture specificity by exploring causal relationships 
      of brain networks following acupuncture at GB40 (Qiuxu), with the acupoint KI3 
      (Taixi) as a control (belonging to the same nerve segment but different 
      meridians). MATERIALS AND METHODS: Needling at acupoints GB40 and KI3 was 
      performed in 12 subjects separately. The specific coherent patterns, 
      resting-state networks (RSNs), were retrieved by independent component analysis 
      (ICA) from functional magnetic resonance imaging (fMRI) data of resting state and 
      post-acupuncture resting states, respectively. Then multivariate Granger 
      causality analysis (mGCA) was applied to evaluate the effective connectivity 
      within and among the detected RSNs-default model, memory, executive, auditory, 
      and motor brain networks. RESULTS: Following acupuncture at GB40, the strength of 
      causal connectivity between the superior temporal gyrus (STG) and anterior insula 
      was enhanced, while the connection strength between the STG and postcentral gyrus 
      increased following acupuncture at KI3. Additionally, the causal influences 
      within the auditory network increased following acupuncture at GB40, in 
      comparison with the executive network following acupuncture at KI3. CONCLUSION: 
      The current study demonstrates that acupuncture at different acupoints could 
      exert different modulatory effects on RSNs. Our findings may help to understand 
      the neurophysiological mechanisms underlying acupuncture specificity.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Zhong, Chongguang
AU  - Zhong C
AD  - Medical Image Processing Group, Institute of Automation, Chinese Academy of 
      Sciences, Beijing, China.
FAU - Bai, Lijun
AU  - Bai L
FAU - Dai, Ruwei
AU  - Dai R
FAU - Xue, Ting
AU  - Xue T
FAU - Wang, Hu
AU  - Wang H
FAU - Feng, Yuanyuan
AU  - Feng Y
FAU - Liu, Zhenyu
AU  - Liu Z
FAU - You, Youbo
AU  - You Y
FAU - Chen, Shangjie
AU  - Chen S
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111108
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Acupuncture Points
MH  - Acupuncture Therapy/*methods
MH  - Algorithms
MH  - Brain Mapping/*methods
MH  - Causality
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Models, Statistical
MH  - Nerve Net/*physiology
MH  - Rest/physiology
MH  - Young Adult
EDAT- 2011/11/10 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/10/11 00:00 [accepted]
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1002/jmri.22887 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2012 Mar;35(3):572-81. doi: 10.1002/jmri.22887. Epub 2011 
      Nov 8.