PMID- 22069276
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20221207
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 27
IP  - 8
DP  - 2011 Nov
TI  - Killer cell immunoglobulin-like receptor along with HLA-C ligand genes are 
      associated with type 1 diabetes in Chinese Han population.
PG  - 872-7
LID - 10.1002/dmrr.1264 [doi]
AB  - OBJECTIVE: Killer cell immunoglobulin-like receptor (KIR) genes and their 
      putative ligands human leukocyte antigen (HLA)-C genes have been associated with 
      type 1 diabetes (T1D). We hypothesize that KIR genes and their ligands HLA-C 
      genes are important in T1D aetiology. RESEARCH DESIGN AND METHODS: KIR and HLA-C 
      ligand genotyping was performed in 259 T1D patients and 262 healthy children. 
      RESULTS: No significant difference was observed in the distribution of KIR genes 
      between T1D patients and healthy controls. However, frequency of HLA-C1 gene and 
      HLA-C2 gene (marginal association) was higher in patient group. The combinations 
      2DL2-/HLA-C1+; 2DL3+/HLA-C1+; 2DS2-/HLAC1+ were positively associated with T1D. 
      The combinations 2DL1+/HLA-C2-; 2DL2-/HLA-C1-; 2DL3+/HLA-C1-; 2DS2-/HLAC1- were 
      found to be negatively associated with T1D. Among the genes we tested, a 
      combination of HLA-C1 and -C2 conferred the strongest association with T1D and 
      the strength of this association was higher than that of HLA-C1 alone. The 
      frequencies of KIR 2DL1, 2DL2 and 2DL3 and HLA-C1 were higher in T1D patients 
      positive for GAD65 autoantibody; frequency of KIR 2DS4 is higher in T1D patients 
      positive for IA-2 autoantibody. The association between KIR/HLA-C gene and 
      autoantibody status was not statistically significant after applying Bonferroni 
      correction. CONCLUSION: In our study of a Han population (East China), we found 
      no direct association of KIR genes with T1D. However, a combination of HLA-C1 and 
      -C2 showed a positive association with T1D. Different combinations of HLA-C and 
      KIR showed positive and negative association with T1D.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Zhi, Dijing
AU  - Zhi D
AD  - Department of Pediatric, Endocrinology and Inherited Metabolic Disease, 
      Children's Hospital of Fudan University, Shanghai, China.
FAU - Sun, Chengjun
AU  - Sun C
FAU - Sedimbi, Saikiran K
AU  - Sedimbi SK
FAU - Luo, Feihong
AU  - Luo F
FAU - Shen, Shuixian
AU  - Shen S
FAU - Sanjeevi, Carani B
AU  - Sanjeevi CB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (HLA-C Antigens)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL1)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 2)
SB  - IM
MH  - Asian People/genetics
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Diabetes Mellitus, Type 1/*genetics/immunology
MH  - Female
MH  - Glutamate Decarboxylase/genetics
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Ligands
MH  - Male
MH  - Receptors, KIR/*genetics
MH  - Receptors, KIR2DL1
EDAT- 2011/11/10 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1002/dmrr.1264 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2011 Nov;27(8):872-7. doi: 10.1002/dmrr.1264.