PMID- 22069282
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20221207
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 27
IP  - 8
DP  - 2011 Nov
TI  - Discordant association of islet autoantibodies with high-risk HLA genes in 
      Chinese type 1 diabetes.
PG  - 899-905
LID - 10.1002/dmrr.1270 [doi]
AB  - BACKGROUND: To reveal the aetiology of diabetes, the relationships between the 
      islet autoantibodies, human leukocyte antigen (HLA)-A and DRB1 genotypes in the 
      Chinese patients with type l diabetes (T1D) were investigated in our study. 
      METHODS: In the cross-sectional and case-control study, peripheral blood samples 
      were collected from 600 T1D patients and 102 healthy controls. The genetic 
      polymorphisms of HLA-A and DRB1 are examined with polymerase chain 
      reaction-sequence oligonucleotide probe method. The zinc transporter 8 antibody 
      (ZnT8A), glutamic acid decarboxylase antibody (GADA) and 
      protein-tyrosine-phosphatase-2 autoantibody (IA2A) were detected by radioligand 
      assay. RESULTS: The A*2402, DRB1*0301, DRB1*0405 and DRB1*0901 alleles, and 
      A*1101-DRB1*0901, A*2402-DRB1*0405 and A*2402-DRB1*0901 haplotypes were 
      associated with T1D (all p<0.05). The positive rates of ZnT8A in patients carried 
      DRB1*0901, IA2A in patients carried DRB1*0405 and A*1101-DRB1*0901 and GADA in 
      patients carried DRB1*0901 and A*2402-DRB1*0901 were significantly higher than 
      those not carried (p<0.05). HLA-DRB1*0901 was the independent risk factor of 
      positive antibody in T1D patients. In addition, higher body mass index is also 
      related with the loss of islet function besides high-risk HLA gene and islet 
      autoantibody (p<0.05). CONCLUSIONS: The discordant association of autoantibodies 
      with high-risk HLA gene may indicate the different immunology mechanisms of those 
      autoantibodies. And metabolic burden resulting from overweight may accelerate 
      apoptosis of beta cells.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Gu, Yong
AU  - Gu Y
AD  - Department of Endocrinology, First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, China.
FAU - Zhang, Mei
AU  - Zhang M
FAU - Chen, Heng
AU  - Chen H
FAU - Wang, Zhixiao
AU  - Wang Z
FAU - Xing, Chunyan
AU  - Xing C
FAU - Yang, Hui
AU  - Yang H
FAU - Xu, Xinyu
AU  - Xu X
FAU - Liu, Yu
AU  - Liu Y
FAU - Zhou, Zhiguang
AU  - Zhou Z
FAU - Yu, Liping
AU  - Yu L
FAU - Hutton, John
AU  - Hutton J
FAU - Eisenbarth, George
AU  - Eisenbarth G
FAU - Yang, Tao
AU  - Yang T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Autoantibodies)
RN  - 0 (Cation Transport Proteins)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (ICA512 autoantibody)
RN  - 0 (SLC30A8 protein, human)
RN  - 0 (Zinc Transporter 8)
RN  - EC 3.1.3.48 (PTPRN protein, human)
RN  - EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 8)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Autoantibodies/analysis/*blood/immunology
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cation Transport Proteins/genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Glutamate Decarboxylase/genetics/immunology
MH  - HLA-A Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Infant
MH  - Islets of Langerhans/*immunology/physiology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptor-Like Protein Tyrosine Phosphatases, Class 8/genetics
MH  - Zinc Transporter 8
EDAT- 2011/11/10 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1002/dmrr.1270 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2011 Nov;27(8):899-905. doi: 10.1002/dmrr.1270.