PMID- 22070029
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20170214
IS  - 0954-4119 (Print)
IS  - 0954-4119 (Linking)
VI  - 225
IP  - 9
DP  - 2011 Sep
TI  - Correlation between intravesical pressure and prostatic obstruction grade using 
      computational fluid dynamics in benign prostatic hyperplasia.
PG  - 920-8
AB  - An urodynamic test which measures various physiologic variables during voiding is 
      generally used for accurate diagnosis of a bladder outlet obstruction (BOO) 
      resulting from benign prostatic hyperplasia (BHP). However, this method is 
      difficult to directly apply to all patients because it is an invasive test and 
      many patients suffer from anxiety and embarrassment during the test. Thus, other 
      diagnosis methods such as uroflowmetry and prostatic symptom score are performed 
      to measure the degree of BOO prior to the urodynamic test, and it is necessary to 
      construct a quantitative relationship among the obstruction level, the 
      intravesical pressure, and the uroflow rate. The aim of this paper is to analyse 
      the variation of intravesical pressure as a function of the extent of the 
      obstruction and the uroflow rate from given information on the size of the 
      bladder and the urodynamic test using a computational fluid dynamics approach. In 
      order to analyse the intravesical pressure, a two-dimensional axisymmetric model 
      of the bladder including a narrowed region, i.e. the prostatic obstruction, is 
      created. Then the variation of the intravesical pressure is quantitatively 
      obtained as a function of the magnitude of the uroflow rate and the extent of the 
      obstruction. It is shown that the intravesical pressure significantly increases 
      even for small obstructions and that at large obstructions it can reach values 
      higher than 100 cm H2O, which is a dangerous value. It is shown that the 
      intravesical pressure decreases as the uroflow rate decreases. This study can 
      form the basis of a non-invasive test for the diagnosis of BHP.
FAU - Lee, M K
AU  - Lee MK
AD  - Department of Mechanical Engineering, Sogang University, South Korea.
FAU - Lee, S H
AU  - Lee SH
FAU - Hur, N
AU  - Hur N
FAU - Kim, S
AU  - Kim S
FAU - Kim, S
AU  - Kim S
FAU - Choi, B
AU  - Choi B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Proc Inst Mech Eng H
JT  - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of 
      engineering in medicine
JID - 8908934
SB  - IM
MH  - Adult
MH  - Computer Simulation
MH  - Diagnostic Techniques, Urological
MH  - Humans
MH  - Male
MH  - *Models, Biological
MH  - Pressure
MH  - Prostatic Hyperplasia/*physiopathology
MH  - Radiography
MH  - Urinary Bladder/diagnostic imaging
MH  - Urinary Bladder Neck Obstruction/*physiopathology
MH  - Urodynamics
EDAT- 2011/11/11 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - 10.1177/0954411911408663 [doi]
PST - ppublish
SO  - Proc Inst Mech Eng H. 2011 Sep;225(9):920-8. doi: 10.1177/0954411911408663.