PMID- 22070577
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20220321
IS  - 1535-3907 (Electronic)
IS  - 1535-3893 (Linking)
VI  - 11
IP  - 2
DP  - 2012 Feb 3
TI  - Analysis of transcriptional factors and regulation networks in laryngeal squamous 
      cell carcinoma patients with lymph node metastasis.
PG  - 1100-7
LID - 10.1021/pr200831g [doi]
AB  - The present study was to identify and quantitate differentially expressed 
      proteins in laryngeal squamous cell carcinoma (LSCC) tissues with or without 
      lymph node metastasis and to explore transcriptional factors and regulation 
      networks associated with the process. Tissue specimens were taken from 20 
      patients with LSCC, including 10 cases of LSCC without metastasis LSCC (N0) and 
      10 cases of LSCC with metastasis LSCC (Nx). Among the 643 unique proteins 
      identified by using iTRAQ labeling and quantitative proteomic technology, 389 
      proteins showed an abundance change in LSCC (Nx) as compared to LSCC (N0). 
      Cytoskeleton remodeling, cell adhesion, and immune response activation were found 
      to be the main processes in LSCC metastasis. The construction of transcription 
      regulation networks identified key transcription regulators for lymph node 
      metastasis of LSCC, including Sp1, c-myc, and p53, which may affect LSCC 
      metastasis through the epithelial-mesenchymal transition. Furthermore, our 
      results suggest that ubiquitination may be a critical factor in the networks. The 
      present study provides insights into transcriptional factors and regulation 
      networks involved in LSCC metastasis, which may lead to new strategies for 
      treatment of LSCC metastasis.
FAU - Cai, Geng-Ming
AU  - Cai GM
AD  - Department of Otolaryngology-Head Neck Surgery, Xiangya Hospital, Central South 
      University , 87 Xiangya Road, Changsha, Hunan, PR China 410008.
FAU - Huang, Dong-Hai
AU  - Huang DH
FAU - Dai, Yao-Zhang
AU  - Dai YZ
FAU - Liu, Yong
AU  - Liu Y
FAU - Pi, Lei-Ming
AU  - Pi LM
FAU - Tan, Hao-Lei
AU  - Tan HL
FAU - Liu, Li-Jun
AU  - Liu LJ
FAU - Lv, Yun-Xia
AU  - Lv YX
FAU - Yu, Chang-Yun
AU  - Yu CY
FAU - Tan, Ping-Qing
AU  - Tan PQ
FAU - Tian, Yong-Quan
AU  - Tian YQ
FAU - Chen, Georgia Z
AU  - Chen GZ
FAU - Zhang, Xin
AU  - Zhang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111128
PL  - United States
TA  - J Proteome Res
JT  - Journal of proteome research
JID - 101128775
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (Sp1 Transcription Factor)
RN  - 0 (TP53 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cell Adhesion
MH  - Cytoskeleton/metabolism
MH  - Down-Regulation
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Protein Interaction Maps
MH  - Proto-Oncogene Proteins c-myc/metabolism
MH  - Sp1 Transcription Factor/metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Transcription Factors/*metabolism
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Up-Regulation
EDAT- 2011/11/11 06:00
MHDA- 2012/07/11 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 10.1021/pr200831g [doi]
PST - ppublish
SO  - J Proteome Res. 2012 Feb 3;11(2):1100-7. doi: 10.1021/pr200831g. Epub 2011 Nov 
      28.