PMID- 22071114
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20120131
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 160
IP  - 2
DP  - 2012 Feb
TI  - Increased CXCL12 expression in the placentae of women with pre-eclampsia.
PG  - 137-41
LID - 10.1016/j.ejogrb.2011.10.007 [doi]
AB  - OBJECTIVE: To investigate the expression pattern of CXC chemokine ligand-12 
      (CXCL12) in the placentae of normal and pre-eclamptic women. STUDY DESIGN: 
      Twenty-five women with severe pre-eclampsia and 30 normotensive women, matched 
      for gestational age, were enrolled in the study. Placental tissue from each woman 
      was collected following delivery by caesarean section. Quantitative reverse 
      transcription polymerase chain reaction, Western blot analysis and 
      immunohistochemical staining were performed for mRNA expression, quantification 
      and tissue localization of CXCL12 in each placenta. RESULTS: CXCL12 expression 
      was greater in pre-eclamptic placentae compared with normal placentae. CXCL12 was 
      detected in most placental tissue cells by immunohistochemical staining. CXCL12 
      immunoreactivity was significantly greater in syncytiotrophoblasts of 
      pre-eclamptic placentae compared with normal placentae. However, there was no 
      significant difference in CXCL12 immunoreactivity in other tissues between the 
      two groups. CONCLUSION: CXCL12 expression is significantly greater in the 
      placentae of pre-eclamptic women compared with normal women. This may represent 
      part of a compensatory mechanism for pre-eclampsia.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Hwang, Han Sung
AU  - Hwang HS
AD  - Department of Obstetrics and Gynaecology, Konkuk University Medical Centre, 
      Konkuk University School of Medicine, Seoul, Republic of Korea.
FAU - Kwon, Han Sung
AU  - Kwon HS
FAU - Sohn, In Sook
AU  - Sohn IS
FAU - Park, Yong Won
AU  - Park YW
FAU - Kim, Young Han
AU  - Kim YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111108
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Academic Medical Centers
MH  - Adult
MH  - Blotting, Western
MH  - Chemokine CXCL12/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Organ Specificity
MH  - Placenta/*metabolism/pathology
MH  - Pre-Eclampsia/*metabolism/pathology/physiopathology
MH  - Pregnancy
MH  - Pregnancy Proteins/genetics/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Severity of Illness Index
MH  - Trophoblasts/metabolism/pathology
MH  - *Up-Regulation
EDAT- 2011/11/11 06:00
MHDA- 2012/06/22 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/07/25 00:00 [revised]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - S0301-2115(11)00595-1 [pii]
AID - 10.1016/j.ejogrb.2011.10.007 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2012 Feb;160(2):137-41. doi: 
      10.1016/j.ejogrb.2011.10.007. Epub 2011 Nov 8.