PMID- 22071579
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20220309
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 459
IP  - 6
DP  - 2011 Dec
TI  - TLE1 is expressed in the majority of primary pleuropulmonary synovial sarcomas.
PG  - 615-21
LID - 10.1007/s00428-011-1160-4 [doi]
AB  - Pleuropulmonary synovial sarcoma (PPSS) is a rare entity, similar to synovial 
      sarcoma of soft tissue (STSS). There are 120 published cases of PPSS, but no 
      studies have explored the expression of TLE1. In soft tissues, it has been proven 
      a useful marker, but in tumors of other sites, its expression has not been 
      explored. The main objective was to study the expression and diagnostic 
      sensitivity and specificity of TLE1 in a group of PPSS, of which the diagnosis 
      was corroborated by fluorescence in situ hybridization confirming t(X;18) in a 
      tissue microarray. Immunohistochemistry including TLE1, vimentin, CD99, CD56, 
      bcl-2, AE1-AE3, EMA, CD34, CK7, CK19, calponin, and S-100 was performed on all 
      PPSS and on 25 control cases (five carcinomas, ten mesotheliomas, and ten 
      thoracic sarcomas). TLE1 was positive in 11 cases (73.3%); bcl-2 and vimentin in 
      100%; calponin and CD56 in 26.6%; CD99, CK AE1-AE3, CK19, CK7, and EMA in 80%; 
      and S100 negative in all. The only biphasic PPSS was positive for epithelial 
      markers only in the epithelial component. TLE1 was negative in all control cases. 
      TLE1 is expressed in 73% of PPSS, a value inferior to that reported in STSS, but 
      is highly specific for PPSS. TLE1 may therefore be of value in the differential 
      diagnosis of PPSS, but should be used in a panel of antibodies.
CI  - (c) Springer-Verlag 2011
FAU - Lino-Silva, Leonardo Saul
AU  - Lino-Silva LS
AD  - Department of Anatomic Pathology, Instituto Nacional de Cancerologia, Mexico 
      City, Mexico. saul.lino.sil@gmail.com
FAU - Flores-Gutierrez, Juan Pablo
AU  - Flores-Gutierrez JP
FAU - Vilches-Cisneros, Natalia
AU  - Vilches-Cisneros N
FAU - Dominguez-Malagon, Hugo Ricardo
AU  - Dominguez-Malagon HR
LA  - eng
PT  - Journal Article
DEP - 20111110
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Co-Repressor Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (S100 Proteins)
RN  - 0 (TLE1 protein, human)
RN  - 0 (Vimentin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD34/metabolism
MH  - Biomarkers, Tumor/*metabolism
MH  - Co-Repressor Proteins
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/diagnosis/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Repressor Proteins/*metabolism
MH  - Retrospective Studies
MH  - S100 Proteins/metabolism
MH  - Sarcoma, Synovial/diagnosis/*metabolism/pathology
MH  - Sensitivity and Specificity
MH  - Vimentin/metabolism
EDAT- 2011/11/11 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/10/04 00:00 [revised]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.1007/s00428-011-1160-4 [doi]
PST - ppublish
SO  - Virchows Arch. 2011 Dec;459(6):615-21. doi: 10.1007/s00428-011-1160-4. Epub 2011 
      Nov 10.