PMID- 22072443
OWN - NLM
STAT- MEDLINE
DCOM- 20131101
LR  - 20141120
IS  - 1098-1136 (Electronic)
IS  - 0894-1491 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Mar
TI  - Increased p75 neurotrophin receptor expression in the canine distemper virus 
      model of multiple sclerosis identifies aldynoglial Schwann cells that emerge in 
      response to axonal damage.
PG  - 358-71
LID - 10.1002/glia.22270 [doi]
AB  - Gliogenesis under pathophysiological conditions is of particular clinical 
      relevance since it may provide regeneration-promoting cells recruitable for 
      therapeutic purposes. There is accumulating evidence that aldynoglial cells with 
      Schwann cell-like growth-promoting properties emerge in the lesioned CNS. 
      However, the characterization of these cells and the signals triggering their in 
      situ generation have remained enigmatic. In the present study, we used the p75 
      neurotrophin receptor (p75(NTR) ) as a marker for Schwann cells to study 
      gliogenesis in the well-defined canine distemper virus (CDV)-induced 
      demyelination model. White matter lesions of CDV-infected dogs contained bi- to 
      multipolar, p75(NTR) -expressing cells that neither expressed MBP, GFAP, BS-1, or 
      P0 identifying oligodendroglia, astrocytes, microglia, and myelinating Schwann 
      cells nor CDV antigen. Interestingly, p75(NTR) -expression became apparent prior 
      to the onset of demyelination in parallel to the expression of beta-amyloid 
      precursor protein (beta-APP), nonphosphorylated neurofilament (n-NF), BS-1, and CD3, 
      and peaked in subacute lesions with inflammation. To study the role of 
      infiltrating immune cells during differentiation of Schwann cell-like glia, 
      organotypic slice cultures from the normal olfactory bulb were established. 
      Despite the absence of infiltrating lymphocytes and macrophages, a massive 
      appearance of p75(NTR) -positive Schwann-like cells and BS-1-positive microglia 
      was noticed at 10 days in vitro. It is concluded that axonal damage as an early 
      signal triggers the differentiation of tissue-resident precursor cells into 
      p75(NTR) -expressing aldynoglial Schwann cells that retain an immature pre-myelin 
      state. Further studies have to address the role of microglia during this process 
      and the regenerative potential of aldynoglial cells in CDV infection and other 
      demyelinating diseases.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Imbschweiler, Ilka
AU  - Imbschweiler I
AD  - Department of Pathology, University of Veterinary Medicine, Bunteweg 17, D-30559 
      Hannover, Germany.
FAU - Seehusen, Frauke
AU  - Seehusen F
FAU - Peck, Claas-Tido
AU  - Peck CT
FAU - Omar, Mohamed
AU  - Omar M
FAU - Baumgartner, Wolfgang
AU  - Baumgartner W
FAU - Wewetzer, Konstantin
AU  - Wewetzer K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111109
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Antigens, CD)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (Sulfides)
RN  - 0 (Viral Proteins)
RN  - 3K9958V90M (Ethanol)
RN  - 4428-14-2 (bis(2-hydroxyethyl)trisulfide)
SB  - IM
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Disease Models, Animal
MH  - Distemper/*complications
MH  - Distemper Virus, Canine/pathogenicity
MH  - Dogs
MH  - Ethanol/analogs & derivatives/metabolism
MH  - Gene Expression Regulation, Viral/physiology
MH  - Multiple Sclerosis/*etiology/*pathology/virology
MH  - Olfactory Bulb/pathology/virology
MH  - Oligodendroglia/*metabolism
MH  - Organ Culture Techniques
MH  - Receptor, Nerve Growth Factor/genetics/*metabolism
MH  - Schwann Cells/*metabolism/pathology
MH  - Sulfides/metabolism
MH  - Viral Proteins/metabolism
EDAT- 2011/11/11 06:00
MHDA- 2013/11/02 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/07/18 00:00 [received]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2013/11/02 06:00 [medline]
AID - 10.1002/glia.22270 [doi]
PST - ppublish
SO  - Glia. 2012 Mar;60(3):358-71. doi: 10.1002/glia.22270. Epub 2011 Nov 9.