PMID- 22072493
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20231115
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 131
IP  - 4
DP  - 2012 Aug 15
TI  - Dietary total antioxidant capacity and gastric cancer risk in the European 
      prospective investigation into cancer and nutrition study.
PG  - E544-54
LID - 10.1002/ijc.27347 [doi]
AB  - A high intake of dietary antioxidant compounds has been hypothesized to be an 
      appropriate strategy to reduce gastric cancer (GC) development. We investigated 
      the effect of dietary total antioxidant capacity (TAC) in relation to GC in the 
      European Prospective Investigation into Cancer (EPIC) study including 23 centers 
      in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 
      35-70 years old, were recruited largely between 1992 and 1998. Ferric reducing 
      antioxidant potential (FRAP) and total radical-trapping antioxidant parameter 
      (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to 
      measure dietary TAC from plant foods. Dietary antioxidant intake is associated 
      with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI 
      (0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs. lowest 
      quintile). The association was observed for both cardia and noncardia cancers. A 
      clear effect was observed in smokers with a significant reduction in GC risk for 
      the fifth quintile of intake for both assays (highest vs. lowest quintile: 
      adjusted HR 0.41; 95%CI (0.22-0.76) p for trend <0.001 for FRAP; adjusted HR 
      0.52; 95%CI (0.28-0.97) p for trend <0.001 for TRAP) but not in nonsmokers. In 
      former smokers, the association with FRAP intake was statistically significant 
      (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.21-0.75) p < 0.05); no 
      association was observed for TRAP. Dietary antioxidant capacity intake from 
      different sources of plant foods is associated with a reduction in the risk of 
      GC.
CI  - Copyright (c) 2011 UICC.
FAU - Serafini, Mauro
AU  - Serafini M
AD  - Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Rome, Italy.
FAU - Jakszyn, Paula
AU  - Jakszyn P
FAU - Lujan-Barroso, Leila
AU  - Lujan-Barroso L
FAU - Agudo, Antonio
AU  - Agudo A
FAU - Bas Bueno-de-Mesquita, H
AU  - Bas Bueno-de-Mesquita H
FAU - van Duijnhoven, Franzel J B
AU  - van Duijnhoven FJ
FAU - Jenab, Mazda
AU  - Jenab M
FAU - Navarro, Carmen
AU  - Navarro C
FAU - Palli, Domenico
AU  - Palli D
FAU - Boeing, Heiner
AU  - Boeing H
FAU - Wallstrom, Peter
AU  - Wallstrom P
FAU - Regner, Sara
AU  - Regner S
FAU - Numans, Mattijs E
AU  - Numans ME
FAU - Carneiro, Fatima
AU  - Carneiro F
FAU - Boutron-Ruault, Marie-Christine
AU  - Boutron-Ruault MC
FAU - Clavel-Chapelon, Francoise
AU  - Clavel-Chapelon F
FAU - Morois, Sophie
AU  - Morois S
FAU - Grioni, Sara
AU  - Grioni S
FAU - Panico, Salvatore
AU  - Panico S
FAU - Tumino, Rosario
AU  - Tumino R
FAU - Sacerdote, Carlotta
AU  - Sacerdote C
FAU - Ramon Quiros, Jose
AU  - Ramon Quiros J
FAU - Molina-Montes, Esther
AU  - Molina-Montes E
FAU - Huerta Castano, Jose M
AU  - Huerta Castano JM
FAU - Barricarte, Aurelio
AU  - Barricarte A
FAU - Amiano, Pilar
AU  - Amiano P
FAU - Khaw, Kay-Tee
AU  - Khaw KT
FAU - Wareham, Nicholas
AU  - Wareham N
FAU - Allen, Naomi E
AU  - Allen NE
FAU - Key, Timothy J
AU  - Key TJ
FAU - Jeurnink, Suzanne M
AU  - Jeurnink SM
FAU - Peeters, Petra H M
AU  - Peeters PH
FAU - Bamia, Christina
AU  - Bamia C
FAU - Valanou, Elisabeth
AU  - Valanou E
FAU - Trichopoulou, Antonia
AU  - Trichopoulou A
FAU - Kaaks, Rudolf
AU  - Kaaks R
FAU - Lukanova, Annekatrin
AU  - Lukanova A
FAU - Bergmann, Manuela M
AU  - Bergmann MM
FAU - Lindkvist, Bjorn
AU  - Lindkvist B
FAU - Stenling, Roger
AU  - Stenling R
FAU - Johansson, Ingegerd
AU  - Johansson I
FAU - Dahm, Christina C
AU  - Dahm CC
FAU - Overvad, Kim
AU  - Overvad K
FAU - Jensen, Majken
AU  - Jensen M
FAU - Olsen, Anja
AU  - Olsen A
FAU - Tjonneland, Anne
AU  - Tjonneland A
FAU - Lund, Eiliv
AU  - Lund E
FAU - Rinaldi, Sabina
AU  - Rinaldi S
FAU - Michaud, Dominique
AU  - Michaud D
FAU - Mouw, Traci
AU  - Mouw T
FAU - Riboli, Elio
AU  - Riboli E
FAU - Gonzalez, Carlos A
AU  - Gonzalez CA
LA  - eng
GR  - 14136/CRUK_/Cancer Research UK/United Kingdom
GR  - G0401527/MRC_/Medical Research Council/United Kingdom
GR  - G1000143/MRC_/Medical Research Council/United Kingdom
GR  - MC_U106179471/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120131
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antioxidants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/*administration & dosage
MH  - *Diet
MH  - Europe/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stomach Neoplasms/*epidemiology/prevention & control
EDAT- 2011/11/11 06:00
MHDA- 2012/09/01 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/01/24 00:00 [received]
PHST- 2011/07/22 00:00 [accepted]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
AID - 10.1002/ijc.27347 [doi]
PST - ppublish
SO  - Int J Cancer. 2012 Aug 15;131(4):E544-54. doi: 10.1002/ijc.27347. Epub 2012 Jan 
      31.