PMID- 22074592
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20211203
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Jun
TI  - Effectiveness and tissue compatibility of a 12-week treatment of chronic venous 
      leg ulcers with an octenidine based antiseptic--a randomized, double-blind 
      controlled study.
PG  - 316-23
LID - 10.1111/j.1742-481X.2011.00886.x [doi]
AB  - The aim of this study was to evaluate the cytotoxic effect of octenidine 
      dihydrochloride/phenoxyethanol (OHP) found in vitro by conducting a randomized, 
      double-blind controlled clinical study focusing on its safe and effective use in 
      chronic venous leg ulcers. In total, 126 male and female patients were treated 
      with either OHP (n = 60) or Ringer solution (n = 66). The treatment lasted over a 
      period of maximum 12 weeks. For the assessment of the wound-healing process, 
      clinical outcome parameters were employed, that is, time span until 100% 
      epithelization, wound status and the wound surface area were analysed. Side 
      effects were recorded during the study period. The median time to complete ulcer 
      healing was comparable between the OHP and Ringer solution groups (92 versus 87 
      days; P = 0.952), without being influenced by wound size or duration of the 
      target ulcer (P-values: 0.947/0.978). In patients treated with OHP, fewer adverse 
      events (AEs) were observed compared with the Ringer group (17% versus 29% of 
      patients reported 20 versus 38 AEs). OHP is well suitable for the treatment of 
      chronic wounds without cytotoxic effects. Furthermore, OHP does not impair the 
      wound healing in chronic venous ulcers.
CI  - (c) 2011 The Authors. (c) 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
FAU - Vanscheidt, Wolfgang
AU  - Vanscheidt W
AD  - wolfgangvanscheidt@t-online.de
FAU - Harding, Keith
AU  - Harding K
FAU - Teot, Luc
AU  - Teot L
FAU - Siebert, Jorg
AU  - Siebert J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20111110
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Imines)
RN  - 0 (Pyridines)
RN  - OZE0372S5A (octenidine)
SB  - IM
MH  - Aged
MH  - Anti-Infective Agents, Local/administration & dosage/*therapeutic use
MH  - Chronic Disease
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - *Histocompatibility
MH  - Humans
MH  - Imines
MH  - Male
MH  - *Occlusive Dressings
MH  - Pyridines/administration & dosage/*therapeutic use
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
MH  - Varicose Ulcer/*drug therapy/immunology/pathology
MH  - Wound Healing/drug effects/*immunology
PMC - PMC7951026
EDAT- 2011/11/15 06:00
MHDA- 2012/11/01 06:00
PMCR- 2011/11/10
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
PHST- 2011/11/10 00:00 [pmc-release]
AID - IWJ886 [pii]
AID - 10.1111/j.1742-481X.2011.00886.x [doi]
PST - ppublish
SO  - Int Wound J. 2012 Jun;9(3):316-23. doi: 10.1111/j.1742-481X.2011.00886.x. Epub 
      2011 Nov 10.