PMID- 22075154
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20151119
IS  - 1532-2165 (Electronic)
IS  - 1078-5884 (Linking)
VI  - 43
IP  - 2
DP  - 2012 Feb
TI  - Circulating lipoprotein-associated phospholipase A2 in high-grade carotid 
      stenosis: a new biomarker for predicting unstable plaque.
PG  - 154-9
LID - 10.1016/j.ejvs.2011.10.009 [doi]
AB  - OBJECTIVE: To test plasma levels of lipoprotein-associated phospholipase A2 
      (Lp-PLA2) in patients with high-grade carotid stenosis according to plaque 
      histology. METHODS: This cross-sectional single-centre study included patients 
      with >/=70% North American Symptomatic Carotid Endarterectomy Trial (NASCET) 
      carotid stenosis, who were treated surgically. Serum Lp-PLA2 and high-sensitivity 
      C-reactive protein (hs-CRP) were determined on the day of surgery. 
      Histopathological analysis classified carotid plaque as stable or unstable, 
      according to AHA classification. RESULTS: Of the 42 patients (mean age 
      70.4 +/- 10.5 years; 67% men), neurological symptoms were present in 16 (38%). 
      Unstable plaques were found in 23 (55%). Median plasma level of Lp-PLA2 was 
      significantly higher in patients with unstable plaque compared to those with 
      stable plaque (222.4 (174.9-437.5) interquartile range (IQR) 63.5 vs. 211.1 
      (174.9-270.6) IQR 37.2 ng ml(-1); p = 0.02). Moreover, median Lp-PLA2 level were 
      higher in asymptomatic patients with unstable plaque (226.8 ng ml(-1) 
      (174.9-437.5) IQR 76.8) vs. stable plaque (206.9 ng ml(-1) (174.9-270.6) IQR 
      33.7; p = 0.16). Logistic regression showed that only the neurological symptoms 
      (OR = 30.9 (3.7-244.6); p < 0.001) and the plasma Lp-PLA2 level (OR = 1.7 
      (1.1-12.3); p = 0.03) were independently associated with unstable carotid plaque 
      as defined by histology. CONCLUSIONS: This study showed that circulating Lp-PLA2 
      was increased in patients with high-grade carotid stenosis and unstable plaque. 
      Lp-PLA2 may be a relevant biomarker to guide for invasive therapy in asymptomatic 
      patients with carotid artery disease.
CI  - Copyright (c) 2011 European Society for Vascular Surgery. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Sarlon-Bartoli, G
AU  - Sarlon-Bartoli G
AD  - Service de Chirurgie Vasculaire, Faculte de Medecine de Marseille, Universite de 
      la Mediterranee, Assistance Publique Hopitaux de Marseille-Hopital de la Timone, 
      13005 Marseille, France. gabrielle.sarlon@ap-hm.fr
FAU - Boudes, A
AU  - Boudes A
FAU - Buffat, C
AU  - Buffat C
FAU - Bartoli, M A
AU  - Bartoli MA
FAU - Piercecchi-Marti, M D
AU  - Piercecchi-Marti MD
FAU - Sarlon, E
AU  - Sarlon E
FAU - Arnaud, L
AU  - Arnaud L
FAU - Bennis, Y
AU  - Bennis Y
FAU - Thevenin, B
AU  - Thevenin B
FAU - Squarcioni, C
AU  - Squarcioni C
FAU - Nicoli, F
AU  - Nicoli F
FAU - Dignat-George, F
AU  - Dignat-George F
FAU - Sabatier, F
AU  - Sabatier F
FAU - Magnan, P E
AU  - Magnan PE
CN  - RISC Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111109
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
SB  - IM
CIN - Eur J Vasc Endovasc Surg. 2012 Feb;43(2):160. PMID: 22119229
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase/*blood
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*blood
MH  - C-Reactive Protein/metabolism
MH  - Carotid Stenosis/*enzymology
MH  - Cross-Sectional Studies
MH  - Endarterectomy, Carotid
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/complications
MH  - Prospective Studies
EDAT- 2011/11/15 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/06/07 00:00 [received]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - S1078-5884(11)00676-9 [pii]
AID - 10.1016/j.ejvs.2011.10.009 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 2012 Feb;43(2):154-9. doi: 10.1016/j.ejvs.2011.10.009. 
      Epub 2011 Nov 9.