PMID- 22075758
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20131121
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Linking)
VI  - 29
IP  - 2
DP  - 2012 Feb
TI  - Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation.
PG  - 303-10
LID - 10.3892/ijmm.2011.829 [doi]
AB  - In this study, we investigated the effect of a water extract of the ripe fruits 
      of Rubus coreanus Miq. (Rosaceae) (RFRC) on mast cell-mediated allergic 
      inflammation and studied the possible mechanism of action. Mast cell-mediated 
      allergic disease is involved in many diseases such as anaphylaxis, rhinitis, 
      asthma and atopic dermatitis. RFRC dose-dependently inhibited compound 
      48/80-induced systemic anaphylaxis and serum histamine release in mice. RFRC 
      reduced the immunoglobulin E (IgE)-mediated local allergic reaction, passive 
      cutaneous anaphylaxis. RFRC attenuated histamine release from rat peritoneal mast 
      cells and human mast cells by the reduction of intracellular calcium. RFRC 
      decreased the phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore 
      A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines 
      in human mast cells. The inhibitory effect of RFRC on cytokine production was 
      nuclear factor (NF)-kappaB- and mitogen-activated protein kinase (MAPK)-dependent. In 
      addition, RFRC suppressed the activation of caspase-1. Our findings provide 
      evidence that RFRC inhibits mast cell-derived allergic inflammatory reactions, 
      and for the involvement of calcium, NF-kappaB, MAPKs and caspase-1 in these effects. 
      Furthermore, in vivo and in vitro anti-allergic inflammatory effects of RFRC 
      provide affirmative proof of a possible therapeutic application of this agent in 
      allergic inflammatory diseases.
FAU - Kim, Hui-Hun
AU  - Kim HH
AD  - Department of Pharmacology, School of Medicine, Kyungpook National University, 
      Daegu 700-422, Republic of Korea.
FAU - Choi, Phil Hyung
AU  - Choi PH
FAU - Yoo, Jin-Su
AU  - Yoo JS
FAU - Jeon, Hoon
AU  - Jeon H
FAU - Chae, Byeong-Suk
AU  - Chae BS
FAU - Park, Jeong-Suk
AU  - Park JS
FAU - Kim, Sang-Hyun
AU  - Kim SH
FAU - Shin, Tae-Yong
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111107
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (Inflammation Mediators)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.4.22.36 (Caspase 1)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Anaphylaxis/chemically induced/*immunology
MH  - Animals
MH  - Calcium/metabolism
MH  - Caspase 1/metabolism
MH  - Cell Line
MH  - Disease Models, Animal
MH  - Enzyme Activation/drug effects
MH  - Fruit/*chemistry
MH  - Gene Expression/drug effects
MH  - Histamine Release/drug effects
MH  - Humans
MH  - Inflammation/immunology
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Mast Cells/*drug effects/*immunology
MH  - Mice
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-kappa B/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rosaceae/*chemistry
MH  - p-Methoxy-N-methylphenethylamine/adverse effects
EDAT- 2011/11/15 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2011/10/04 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - 10.3892/ijmm.2011.829 [doi]
PST - ppublish
SO  - Int J Mol Med. 2012 Feb;29(2):303-10. doi: 10.3892/ijmm.2011.829. Epub 2011 Nov 
      7.