PMID- 22076171
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 4
IP  - 7
DP  - 2011
TI  - Small oncocytic papillary renal cell carcinoma in diabetic glomerulosclerosis.
PG  - 708-12
AB  - Histologic and immunohistochemical features of oncocytic papillary renal cell 
      carcinoma (RCC) have not been fully elucidated. The author herein report a case 
      of oncocytic papillary RCC (OPRCC). A 71-year-old man with diabetes mellitus and 
      diabetic nephropathy was found to have a small right renal tumor by CT. He had 
      been treated with hemodialysis for chronic renal failure for 10 years. A 
      nephrectomy was performed. Grossly, a small (1.5cm) encapsulated yellow tumor was 
      found in the kidney. Histologically, the tumor was completely encapsulated, and 
      consisted entirely of atypical oncocytes arranged in a diffuse papillary 
      structure with fibrovascular cores. The oncocytes showed grade 3 atypia and 
      pseudostratification. A few mitotic figures were seen, and psammoma bodies, foamy 
      macrophages, and hemosiderin were scattered. Histochemically, the tumor cells 
      were positive for colloidal iron, and negative for mucins (Alcian blue/PAS). 
      Immunohistochemical results of the tumor were as follows: alpha-methylacyl-coenzyme A 
      rasemase (AMACR) +++, vimentin +++, cytokeratin (CK) 18 +++, CD10 +++, S-100 
      protein +, MUC1 ++, MUC2 ++, MUC5AC ++, MUC6 ++, panCK Cam5.2 +, CK7 +, CK8 +, 
      CK14 +, CK19 +, CK20 +, p53 +, HepPar1 +, CD68 +, platelet-derived growth 
      factor-alpha (PDGFRA) +, PanCK AE1/3 -, PanCK WSS -, PanCK MNF115 -, CK 35BE12 -, 
      CK5/6 -, EMA -, desmin -, smooth muscle antigen -, alpha-fetoprotein -, CEA -, 
      estrogen receptor -, progesterone receptor -, HER2 -, p63 -, and KIT -. Ki67 
      labeling was 6%. These results suggest that OPRCC can express colloidal iron, low 
      molecular weight CKs, S100 protein, MUC1, MUC2, MUC5AC, MUC6, p53, PDGFRA, and 
      HepPar1.
FAU - Terada, Tadashi
AU  - Terada T
AD  - Departments of Pathology, Shizuoka City Shimizu Hospital Shizuoka, Japan. 
      piyo0111jp@yahoo.co.jp
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111016
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Papillary/chemistry/*etiology/pathology/surgery
MH  - Carcinoma, Renal Cell/chemistry/*etiology/pathology/surgery
MH  - Diabetic Nephropathies/*complications/therapy
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney Neoplasms/chemistry/*etiology/pathology/surgery
MH  - Male
MH  - Nephrectomy
MH  - *Oxyphil Cells/chemistry/pathology
MH  - Renal Dialysis
PMC - PMC3209611
OTO - NOTNLM
OT  - Oncocytic papillary renal cell carcinoma (OPRCC)
OT  - immunohistochemistry
EDAT- 2011/11/15 06:00
MHDA- 2012/03/03 06:00
PMCR- 2011/10/16
CRDT- 2011/11/15 06:00
PHST- 2011/08/13 00:00 [received]
PHST- 2011/10/09 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
PHST- 2011/10/16 00:00 [pmc-release]
PST - ppublish
SO  - Int J Clin Exp Pathol. 2011;4(7):708-12. Epub 2011 Oct 16.