PMID- 2207662
OWN - NLM
STAT- MEDLINE
DCOM- 19901109
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 521
IP  - 1-2
DP  - 1990 Jun 25
TI  - Regulated release of multiple peptides from the bag cell neurons of Aplysia 
      californica.
PG  - 229-37
AB  - The bag cell neurons of Aplysia californica synthesize and store large amounts of 
      peptides derived from the egg-laying-hormone (ELH) neuropeptide precursor. 
      Different sets of peptides derived from the amino- and carboxyl-terminal regions 
      of the prohormone possess unique biological activities, and are packaged in 
      distinct sets of secretory granules. We report here quantitative measurements of 
      the amounts of the peptide products stored in and released from the bag cell 
      neurons using high pressure liquid chromatography (HPLC) and amino acid 
      composition analysis. These studies demonstrate that both the autocrine acting 
      bag cell peptides (BCPs) and ELH are released coincident with electrical activity 
      in the bag cell cluster. The composition of the released peptide mixture is 
      similar to that stored in the bag cells. ELH and other carboxy-terminal derived 
      peptides are most often present at 5-fold greater levels than the BCPs. These 
      results provide further insight into the use of multiple chemical messengers by 
      the bag cell neurons.
FAU - Newcomb, R W
AU  - Newcomb RW
AD  - Department of Biological Sciences, Stanford University, CA 94305.
FAU - Scheller, R H
AU  - Scheller RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Invertebrate Hormones)
RN  - 0 (Protein Precursors)
RN  - 0 (egg-laying hormone, Mollusca)
SB  - IM
MH  - Animals
MH  - Aplysia/*metabolism
MH  - Invertebrate Hormones/*metabolism
MH  - Neurons/*metabolism
MH  - Protein Precursors/*metabolism
MH  - Protein Processing, Post-Translational/*physiology
EDAT- 1990/06/25 00:00
MHDA- 1990/06/25 00:01
CRDT- 1990/06/25 00:00
PHST- 1990/06/25 00:00 [pubmed]
PHST- 1990/06/25 00:01 [medline]
PHST- 1990/06/25 00:00 [entrez]
AID - 0006-8993(90)91547-T [pii]
AID - 10.1016/0006-8993(90)91547-t [doi]
PST - ppublish
SO  - Brain Res. 1990 Jun 25;521(1-2):229-37. doi: 10.1016/0006-8993(90)91547-t.