PMID- 22079189
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20220408
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Electronic)
IS  - 0968-0004 (Linking)
VI  - 37
IP  - 1
DP  - 2012 Jan
TI  - The ATM protein kinase and cellular redox signaling: beyond the DNA damage 
      response.
PG  - 15-22
LID - 10.1016/j.tibs.2011.10.002 [doi]
AB  - The ataxia-telangiectasia mutated (ATM) protein kinase is best known for its role 
      in the DNA damage response, but recent findings suggest that it also functions as 
      a redox sensor that controls the levels of reactive oxygen species in human 
      cells. Here, we review evidence supporting the conclusion that ATM can be 
      directly activated by oxidation, as well as various observations from 
      ATM-deficient patients and mouse models that point to the importance of ATM in 
      oxidative stress responses. We also discuss the roles of this kinase in 
      regulating mitochondrial function and metabolic control through its action on 
      tumor suppressor p53, AMP-activated protein kinase (AMPK), mammalian target of 
      rapamycin (mTOR) and hypoxia-inducible factor 1 (HIF1), and how the regulation of 
      these enzymes may be affected in ATM-deficient patients and in cancer cells.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Ditch, Scott
AU  - Ditch S
AD  - The Howard Hughes Medical Institute, The Department of Molecular Genetics and 
      Microbiology, The University of Texas at Austin, Austin, TX 78712, USA.
FAU - Paull, Tanya T
AU  - Paull TT
LA  - eng
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01 CA132813/CA/NCI NIH HHS/United States
GR  - R01 CA132813-04/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20111111
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (ATM protein, human)
RN  - EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins)
RN  - EC 2.7.11.1 (Atm protein, mouse)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Ataxia Telangiectasia Mutated Proteins
MH  - Cell Cycle Proteins/deficiency/*metabolism
MH  - *DNA Damage
MH  - DNA-Binding Proteins/deficiency/*metabolism
MH  - Glutathione/metabolism
MH  - Humans
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - Protein Serine-Threonine Kinases/deficiency/*metabolism
MH  - *Signal Transduction
MH  - Tumor Suppressor Proteins/deficiency/*metabolism
PMC - PMC3259275
MID - NIHMS338317
EDAT- 2011/11/15 06:00
MHDA- 2012/07/03 06:00
PMCR- 2013/01/01
CRDT- 2011/11/15 06:00
PHST- 2011/08/17 00:00 [received]
PHST- 2011/10/06 00:00 [revised]
PHST- 2011/10/07 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - S0968-0004(11)00161-7 [pii]
AID - 10.1016/j.tibs.2011.10.002 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2012 Jan;37(1):15-22. doi: 10.1016/j.tibs.2011.10.002. Epub 
      2011 Nov 11.