PMID- 22079886
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20161222
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Apr
TI  - Mild-to-moderate kidney dysfunction and the risk of sudden cardiac death in the 
      setting of acute myocardial infarction.
PG  - 540-5
LID - 10.1016/j.hrthm.2011.11.014 [doi]
AB  - BACKGROUND: Although end-stage renal disease is known to elevate the risk of 
      sudden cardiac death (SCD), the role of less severe renal impairment in SCD is 
      unclear. OBJECTIVE: The purpose of this study was to examine the association 
      between mild-to-moderate renal impairment and first ischemic ventricular 
      fibrillation (VF). METHODS: Renal function in patients included in the Arrhythmia 
      Genetics in the NEtherlands Study (AGNES) were compared. Cases (n = 337, age 56 +/- 
      1 year, 80% men) were defined as patients who had survived VF at the time of 
      their first acute ST elevation myocardial infarction (STEMI), and controls (n = 
      339, age 58 +/- 1 years, 80% men) were defined as those without VF during their 
      first acute STEMI. Estimated glomerular filtration rate (eGFR) at the time of 
      acute STEMI was computed using the 4-variable Modification of Diet in Renal 
      Disease equation. RESULTS: At eGFR less than 105 mL/min, a decrease in eGFR was 
      associated with elevated odds of developing VF during STEMI. The association was 
      essentially flat at eGFR levels >105 mL/min. The lowest eGFR quintile was 
      associated with a >6-fold increase in odds of developing VF compared to the 
      fourth quintile. This association between eGFR and VF at the time of STEMI 
      remained significant after adjusting for potential confounders including 
      electrolyte levels. CONCLUSION: Mild-to-moderate kidney dysfunction is associated 
      with a significantly elevated risk of VF in the setting of acute STEMI. Further 
      studies are needed to investigate the precise mechanisms by which mild kidney 
      function results in VF.
CI  - Copyright (c) 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Dalal, Darshan
AU  - Dalal D
AD  - Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
FAU - de Jong, Jonas S S G
AU  - de Jong JS
FAU - Tjong, Fleur V Y
AU  - Tjong FV
FAU - Wang, Yaping
AU  - Wang Y
FAU - Bruinsma, Nienke
AU  - Bruinsma N
FAU - Dekker, Lukas R C
AU  - Dekker LR
FAU - Wilde, Arthur A M
AU  - Wilde AA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111110
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
SB  - IM
CIN - Heart Rhythm. 2012 Apr;9(4):546-7. PMID: 22123316
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Confidence Intervals
MH  - Death, Sudden, Cardiac/epidemiology/etiology/*pathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Health Status Indicators
MH  - Heart Arrest/epidemiology/etiology/*pathology
MH  - Humans
MH  - Kidney/*pathology
MH  - Kidney Diseases/*pathology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*epidemiology/etiology/*pathology
MH  - Odds Ratio
MH  - Risk
MH  - Tachycardia, Ventricular/*pathology
EDAT- 2011/11/15 06:00
MHDA- 2012/08/10 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - S1547-5271(11)01332-4 [pii]
AID - 10.1016/j.hrthm.2011.11.014 [doi]
PST - ppublish
SO  - Heart Rhythm. 2012 Apr;9(4):540-5. doi: 10.1016/j.hrthm.2011.11.014. Epub 2011 
      Nov 10.