PMID- 2208031
OWN - NLM
STAT- MEDLINE
DCOM- 19901116
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 66
IP  - 8
DP  - 1990 Oct 15
TI  - Prognostic implication of ecto-5'-nucleotidase activity in acute lymphoblastic 
      leukemia.
PG  - 1755-8
AB  - Ecto-5'-nucleotidase (5'-N) activity was determined in 191 patients (71 children 
      and 120 adults) with acute leukemia. Elevated values for 5'-N were registered in 
      common acute lymphoblastic leukemia (ALL), but blast cells of T-cell ALL (T-ALL) 
      and common ALL antigen-negative non-T-ALL had low enzyme activity comparable with 
      the values of acute non-lymphocytic leukemia. Dependence of remission duration on 
      5'-N activity was analyzed in 74 adults with ALL, treated similarly in a 
      prospective multicenter trial. The remission curves for ALL patients with 5'-N 
      activity lower than 10 nmol/h x 10(6) cells were substantially and significantly 
      better than those of patients with high activity (greater than 10 nmol/h x 10(6) 
      cells). This difference was also evident in the immunologic subclass common ALL. 
      Statistical evaluation showed that an interaction between immunologic subtype of 
      the blast cells and their 5'-N activity had prognostic significance for remission 
      duration. In addition to the independent factor, initial age, this interaction 
      was also prognostic for survival.
FAU - Gutensohn, W
AU  - Gutensohn W
AD  - Institute of Anthropology and Human Genetics, University of Munich, Federal 
      Republic of Germany.
FAU - Thiel, E
AU  - Thiel E
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.1.3.5 (5'-Nucleotidase)
SB  - IM
MH  - 5'-Nucleotidase/blood/*metabolism
MH  - Adult
MH  - Biomarkers, Tumor/blood
MH  - Child
MH  - *Clinical Enzyme Tests
MH  - Humans
MH  - Immunophenotyping
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood/*diagnosis/pathology
MH  - Prognosis
MH  - Prospective Studies
MH  - Remission Induction
EDAT- 1990/10/15 00:00
MHDA- 1990/10/15 00:01
CRDT- 1990/10/15 00:00
PHST- 1990/10/15 00:00 [pubmed]
PHST- 1990/10/15 00:01 [medline]
PHST- 1990/10/15 00:00 [entrez]
AID - 10.1002/1097-0142(19901015)66:8<1755::aid-cncr2820660819>3.0.co;2-j [doi]
PST - ppublish
SO  - Cancer. 1990 Oct 15;66(8):1755-8. doi: 
      10.1002/1097-0142(19901015)66:8<1755::aid-cncr2820660819>3.0.co;2-j.