PMID- 22080497
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 38
IP  - 6
DP  - 2012 Nov
TI  - Risk factors for psychosis: impaired social and role functioning.
PG  - 1247-57
LID - 10.1093/schbul/sbr136 [doi]
AB  - OBJECTIVES: Risk for psychosis is currently defined primarily on the basis of 
      attenuated positive symptoms (APS), with no inclusion of the functional deficits 
      characteristic of schizophrenia. Impaired social and role functioning have been 
      of interest for reflecting poor outcome but far less is known about the 
      developmental impact of these deficits as vulnerability or risk factors. METHODS: 
      Age-appropriate social and role functioning were prospectively assessed in 100 
      individuals at clinical high risk (CHR) for psychosis included in the 8-site 
      North American Prodromal Longitudinal Study database. A nested case-control 
      design was used to compare changes in social and role functioning in 26 
      individuals converting to psychosis shortly after baseline assessment and 24 
      converting over a year later. Individuals in each converter subgroup were 
      directly matched to a non-converter at the same site, controlling for time to 
      conversion, age, gender, and severity of baseline symptoms. RESULTS: At baseline, 
      CHR subjects who later became psychotic were significantly more likely to be 
      impaired socially than matched non-converters. Onset of psychosis did not further 
      disrupt social difficulties. Role functioning showed some of the same trends, but 
      the overall pattern was not as consistent as for the social domain. Controlling 
      for neurocognition did not change the pattern of group differences. CONCLUSIONS: 
      Early impaired social functioning appears to be a risk factor for psychosis and, 
      added to APS, could potentially contribute to accurate identification of CHR 
      individuals and provide a new direction for early intervention to reduce 
      long-term disability.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long 
      Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, USA. 
      Cornblat@lij.edu
FAU - Carrion, Ricardo E
AU  - Carrion RE
FAU - Addington, Jean
AU  - Addington J
FAU - Seidman, Larry
AU  - Seidman L
FAU - Walker, Elaine F
AU  - Walker EF
FAU - Cannon, Tyronne D
AU  - Cannon TD
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
FAU - McGlashan, Thomas H
AU  - McGlashan TH
FAU - Perkins, Diana O
AU  - Perkins DO
FAU - Tsuang, Ming T
AU  - Tsuang MT
FAU - Woods, Scott W
AU  - Woods SW
FAU - Heinssen, Robert
AU  - Heinssen R
FAU - Lencz, Todd
AU  - Lencz T
LA  - eng
GR  - K24 MH76191/MH/NIMH NIH HHS/United States
GR  - R18 MH43518/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - R01 MH062066/MH/NIMH NIH HHS/United States
GR  - R41 MH083436/MH/NIMH NIH HHS/United States
GR  - P50 MH064065/MH/NIMH NIH HHS/United States
GR  - R01 MH061523/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R18 MH 43518/MH/NIMH NIH HHS/United States
GR  - U01 MH74356/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - 5U01 MH081988/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - R01 MH60720/MH/NIMH NIH HHS/United States
GR  - K23 MH001905/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - R01 MH65079/MH/NIMH NIH HHS/United States
GR  - K05 MH01654/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111110
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Odds Ratio
MH  - *Prodromal Symptoms
MH  - Prospective Studies
MH  - Psychotic Disorders/epidemiology/*physiopathology/psychology
MH  - Risk Factors
MH  - *Role
MH  - Social Adjustment
MH  - *Social Behavior
MH  - Social Behavior Disorders/epidemiology/*physiopathology/psychology
MH  - Young Adult
PMC - PMC3494064
EDAT- 2011/11/15 06:00
MHDA- 2013/05/17 06:00
PMCR- 2013/11/01
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - sbr136 [pii]
AID - 10.1093/schbul/sbr136 [doi]
PST - ppublish
SO  - Schizophr Bull. 2012 Nov;38(6):1247-57. doi: 10.1093/schbul/sbr136. Epub 2011 Nov 
      10.