PMID- 22080589
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20151119
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Feb
TI  - Pulmonary oxidative stress is induced by maximal exercise in young cigarette 
      smokers.
PG  - 243-7
LID - 10.1093/ntr/ntr237 [doi]
AB  - INTRODUCTION: Oxidative stress is induced by both cigarette smoking and acute 
      exercise. It has also been reported that exercise can induce plasma oxidative 
      stress in young cigarette smokers. However, no previous report has demonstrated 
      that exercise induces pulmonary oxidative stress in cigarette smokers. The aim of 
      this study was to determine whether pulmonary oxidative stress is induced by 
      maximal exercise in cigarette smokers as measured by reactive oxygen species 
      generation and total antioxidant content. METHODS: Fifteen male smokers (mean 
      age: 25.9 +/- 2.9 years) and 18 male nonsmokers (mean age: 24.2 +/- 4.3 years) 
      participated in this study. Hydrogen peroxide (H(2)O(2)) concentration and 
      biological antioxidant potential (BAP) in exhaled breath condensate (EBC) were 
      measured at baseline and after maximal exercise in the Wingate anaerobic test. 
      RESULTS: A significant interaction of group by time was observed for EBC H2O2 
      concentration (p = .015). After exercise, EBC H(2)O(2) concentrations were 
      significantly increased in the smoking group (p = .030) but not in the nonsmoking 
      group. There were no significant changes in EBC BAP in either group. CONCLUSIONS: 
      These findings indicate that in cigarette smokers, maximal exercise induces 
      pulmonary oxidative stress, which may lead to oxidative damage in the lungs.
FAU - Taito, Shunsuke
AU  - Taito S
AD  - Graduate School of Health Sciences, Hiroshima University, 1-2-3 Kasumi, 
      Minami-ku, Hiroshima 734-8553, Japan.
FAU - Sekikawa, Kiyokazu
AU  - Sekikawa K
FAU - Domen, Sayaka
AU  - Domen S
FAU - Konishi, Kana
AU  - Konishi K
FAU - Kimura, Tatsushi
AU  - Kimura T
FAU - Takahashi, Makoto
AU  - Takahashi M
FAU - Inamizu, Tsutomu
AU  - Inamizu T
FAU - Hamada, Hironobu
AU  - Hamada H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111111
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Adult
MH  - Antioxidants/metabolism
MH  - Biomarkers/metabolism
MH  - Breath Tests
MH  - Case-Control Studies
MH  - Exercise/*physiology
MH  - Exhalation
MH  - Humans
MH  - Hydrogen Peroxide/analysis
MH  - Lung Diseases/metabolism
MH  - Male
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Smoking/*adverse effects/metabolism
MH  - Young Adult
EDAT- 2011/11/15 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - ntr237 [pii]
AID - 10.1093/ntr/ntr237 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2012 Feb;14(2):243-7. doi: 10.1093/ntr/ntr237. Epub 2011 Nov 
      11.