PMID- 2208175
OWN - NLM
STAT- MEDLINE
DCOM- 19901121
LR  - 20181130
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 50
IP  - 21
DP  - 1990 Nov 1
TI  - Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the 
      human lung.
PG  - 7077-80
AB  - We immunohistochemically examined 131 primary human lung adenocarcinomas for the 
      possible presence of autocrine factors. Transforming growth factor alpha (TGF 
      alpha) and epidermal growth factor (EGF) were considered growth factors with 
      epidermal growth factor receptor (EGFR) as the receptor. Of these tumors, 87 
      (66%) showed a high expression of TGF alpha, 66 (50%) showed a high expression of 
      EGF, and 55 (42%) were positive for EGFR reactivity. In the EGFR-positive cases, 
      the 5-year survival rates of patients with high TGF alpha and low TGF alpha were 
      36% and 85%, respectively (P less than 0.05). The 5-year survival rates of 
      patients with high EGF and low EGF were 25% and 77%, respectively (P less than 
      0.05). In contrast, in the EGFR-negative cases, there was no statistical 
      difference between the 5-year survival rates of patients with either high TGF 
      alpha or EGF and low TGF alpha or EGF. Because autocrine growth mechanisms are 
      present in adenocarcinoma of the human lung, these events may contribute to 
      clarification of tumor development, and perhaps even to a better prognosis.
FAU - Tateishi, M
AU  - Tateishi M
AD  - Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
FAU - Ishida, T
AU  - Ishida T
FAU - Mitsudomi, T
AU  - Mitsudomi T
FAU - Kaneko, S
AU  - Kaneko S
FAU - Sugimachi, K
AU  - Sugimachi K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Transforming Growth Factor alpha)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adenocarcinoma/*metabolism/mortality/ultrastructure
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Membrane/metabolism
MH  - Cytoplasm/metabolism
MH  - Epidermal Growth Factor/*metabolism
MH  - ErbB Receptors/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*metabolism/mortality/ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Transforming Growth Factor alpha/*metabolism
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1990 Nov 1;50(21):7077-80.