PMID- 22081934
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Apr
TI  - MCP-1 and CCR2 gene variants and the risk for osteoporosis and osteopenia.
PG  - 229-33
LID - 10.1089/gtmb.2011.0216 [doi]
AB  - AIM: In this study, we investigated whether monocyte chemotactic protein 1 
      (MCP-1) and CC chemokine receptor 2 (CCR2) gene polymorphisms account for an 
      increased risk of osteoporosis or osteopenia. METHODS: Three hundred three 
      postmenopausal women, 80 osteoporotic, 123 osteopenic, and 100 unrelated 
      age-matched healthy controls, were included in the study. Genotyping of MCP-1 
      A2518G and CCR2 V64I gene polymorphisms were detected by PCR-RFLP. RESULTS: We, 
      for the first time, demonstrated the positive association of MCP-1 GG, CCR2 
      Val/Ile, and CCR2 Val+ genotype with osteoporosis risk. However, CCR2 Ile/Ile 
      genotype frequencies were high in the control group compared with those of the 
      patients with osteoporosis and osteopenia. Haplotype analysis confirmed the 
      association of MCP-1/CCR2 gene variants with osteopenia and revealed that the 
      frequency of MCP-1 A:CCR2 Val haplotype was significantly higher in patients when 
      compared with controls. CONCLUSIONS: In conclusion, our findings have suggested 
      that MCP-1 and CCR2 gene variants were risk factors for osteoporosis and 
      osteopenia.
FAU - Eraltan, Hakan
AU  - Eraltan H
AD  - Department of Physical Medicine and Rehabilitation, Azerbaijan Medical 
      University, Baku, Azerbaijan.
FAU - Cacina, Canan
AU  - Cacina C
FAU - Kahraman, Ozlem Timirci
AU  - Kahraman OT
FAU - Kurt, Ozlem
AU  - Kurt O
FAU - Aydogan, Hulya Yilmaz
AU  - Aydogan HY
FAU - Uyar, Mehmet
AU  - Uyar M
FAU - Can, Ayse
AU  - Can A
FAU - Cakmakoglu, Bedia
AU  - Cakmakoglu B
LA  - eng
PT  - Journal Article
DEP - 20111114
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Diseases, Metabolic/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Middle Aged
MH  - Osteoporosis/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Postmenopause
MH  - Receptors, CCR2/*genetics
EDAT- 2011/11/16 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1089/gtmb.2011.0216 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2012 Apr;16(4):229-33. doi: 10.1089/gtmb.2011.0216. 
      Epub 2011 Nov 14.