PMID- 22083420
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20211021
IS  - 1436-3305 (Electronic)
IS  - 1436-3291 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Apr
TI  - CD83(+) dendritic cells and Foxp3(+) regulatory T cells in primary lesions and 
      regional lymph nodes are inversely correlated with prognosis of gastric cancer.
PG  - 144-53
LID - 10.1007/s10120-011-0090-9 [doi]
AB  - BACKGROUND: Dendritic cells (DCs) are potent antigen-presenting cells that are 
      central to the regulation, maturation, and maintenance of the cellular immune 
      response against cancer. In contrast, CD4(+)CD25(+) regulatory T cells (Tregs) 
      play a central role in self-tolerance and suppress antitumor immunity. In this 
      study, we investigated the clinical significance of mature CD83(+) DCs and 
      Foxp3(+) Tregs in the primary tumor and regional lymph nodes from the viewpoint 
      of the two opposing players in the immune responses. METHODS: We investigated, 
      immunohistochemically, the density of CD83(+) DCs and Foxp3(+) Tregs in primary 
      lesions of gastric cancer (n = 123), as well as in regional lymph nodes with 
      (n = 40) or without metastasis (n = 40). RESULTS: Decreased density of CD83(+) 
      DCs and increased density of Foxp3(+) Tregs were observed in the primary tumor 
      and metastatic lymph nodes. Density was significantly correlated with certain 
      clinicopathological features. Poor prognosis was observed in patients with a low 
      density of CD83(+) DCs and a high density of Foxp3(+) Tregs in primary lesions. 
      For patients with metastatic lymph nodes, the density of CD83(+) DCs in negative 
      lymph nodes was found to be an independent prognostic factor by multivariate 
      analysis. CONCLUSION: The density of CD83(+) DCs and Foxp3(+) Tregs was inversely 
      correlated with tumor progression and reflected the prognosis of gastric cancer.
FAU - Kashimura, Seigo
AU  - Kashimura S
AD  - Department of Surgery I, Fukushima Medical University, 1 Hikarigaoka, Fukushima 
      960-1295, Japan.
FAU - Saze, Zenichiro
AU  - Saze Z
FAU - Terashima, Masanori
AU  - Terashima M
FAU - Soeta, Nobutoshi
AU  - Soeta N
FAU - Ohtani, Satoshi
AU  - Ohtani S
FAU - Osuka, Fumihiko
AU  - Osuka F
FAU - Kogure, Michihiko
AU  - Kogure M
FAU - Gotoh, Mitsukazu
AU  - Gotoh M
LA  - eng
PT  - Journal Article
DEP - 20111115
PL  - Japan
TA  - Gastric Cancer
JT  - Gastric cancer : official journal of the International Gastric Cancer Association 
      and the Japanese Gastric Cancer Association
JID - 100886238
RN  - 0 (Antigens, CD)
RN  - 0 (CD84 protein, human)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Signaling Lymphocytic Activation Molecule Family)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigen-Presenting Cells/*immunology
MH  - Antigens, CD/*analysis
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Forkhead Transcription Factors/*analysis
MH  - Humans
MH  - Immune Tolerance
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Lymph Nodes/*immunology/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Signaling Lymphocytic Activation Molecule Family
MH  - Stomach Neoplasms/*immunology/mortality/pathology
MH  - Survival Rate
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Young Adult
EDAT- 2011/11/16 06:00
MHDA- 2013/01/01 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/04/25 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.1007/s10120-011-0090-9 [doi]
PST - ppublish
SO  - Gastric Cancer. 2012 Apr;15(2):144-53. doi: 10.1007/s10120-011-0090-9. Epub 2011 
      Nov 15.