PMID- 22083765 OWN - NLM STAT- MEDLINE DCOM- 20120328 LR - 20111115 IS - 1525-8955 (Electronic) IS - 0885-3010 (Linking) VI - 58 IP - 11 DP - 2011 Nov TI - Dual-pulse frequency compounded superharmonic imaging. PG - 2316-24 LID - 10.1109/TUFFC.2011.2089 [doi] AB - Tissue second-harmonic imaging is currently the default mode in commercial diagnostic ultrasound systems. A new modality, superharmonic imaging (SHI), combines the third through fifth harmonics originating from nonlinear wave propagation through tissue. SHI could further improve the resolution and quality of echographic images. The superharmonics have gaps between the harmonics because the transducer has a limited bandwidth of about 70% to 80%. This causes ghost reflection artifacts in the superharmonic echo image. In this work, a new dual-pulse frequency compounding (DPFC) method to eliminate these artifacts is introduced. In the DPFC SHI method, each trace is constructed by summing two firings with slightly different center frequencies. The feasibility of the method was established using a single-element transducer. Its acoustic field was modeled in KZK simulations and compared with the corresponding measurements obtained with a hydrophone apparatus. Subsequently, the method was implemented on and optimized for a setup consisting of an interleaved phased-array transducer (44 elements at 1 MHz and 44 elements at 3.7 MHz, optimized for echocardiography) and a programmable ultrasound system. DPFC SHI effectively suppresses the ghost reflection artifacts associated with imaging using multiple harmonics. Moreover, compared with the single-pulse third harmonic, DPFC SHI improved the axial resolution by 3.1 and 1.6 times at the -6-dB and -20-dB levels, respectively. Hence, DPFC offers the possibility of generating harmonic images of a higher quality at a cost of a moderate frame rate reduction. FAU - van Neer, Paul L M J AU - van Neer PL AD - Department of Biomedical Engineering, Erasmus Medical Centre, Rotterdam, The Netherlands. FAU - Danilouchkine, Mikhail G AU - Danilouchkine MG FAU - Matte, Guillaume M AU - Matte GM FAU - van der Steen, Anton F W AU - van der Steen AF FAU - de Jong, Nico AU - de Jong N LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - IEEE Trans Ultrason Ferroelectr Freq Control JT - IEEE transactions on ultrasonics, ferroelectrics, and frequency control JID - 9882735 SB - IM MH - *Algorithms MH - Elasticity Imaging Techniques/instrumentation/*methods MH - Image Enhancement/*methods MH - Image Interpretation, Computer-Assisted/*methods MH - Phantoms, Imaging MH - Reproducibility of Results MH - Sensitivity and Specificity MH - *Signal Processing, Computer-Assisted EDAT- 2011/11/16 06:00 MHDA- 2012/03/29 06:00 CRDT- 2011/11/16 06:00 PHST- 2011/11/16 06:00 [entrez] PHST- 2011/11/16 06:00 [pubmed] PHST- 2012/03/29 06:00 [medline] AID - 10.1109/TUFFC.2011.2089 [doi] PST - ppublish SO - IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Nov;58(11):2316-24. doi: 10.1109/TUFFC.2011.2089.