PMID- 22084489
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20151119
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Jun
TI  - Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple 
      sclerosis.
PG  - 799-806
LID - 10.1177/1352458511428081 [doi]
AB  - BACKGROUND: Some of the strongest associations with MS onset are for human 
      herpesviruses, particularly Epstein-Barr virus (EBV) and human herpesvirus 6 
      (HHV-6). Their role in MS clinical course is less clear, however. METHODS: 
      Prospective cohort of 198 persons with clinically definite MS, followed 2002-5, 
      and serum samples obtained from all subjects at study entry to measure anti-HHV-6 
      and anti-EBV (Epstein-Barr nuclear antigen [EBNA] and viral capsid antigen [VCA]) 
      IgG titers. Association with relapse evaluated using survival analysis; 
      association with disability/progression evaluated using linear regression or 
      multilevel mixed-effects linear regression. RESULTS: For the 145 persons with 
      relapsing-remitting MS followed beyond one review, anti-HHV-6 IgG titer was 
      positively associated with the hazard of relapse with a dose-dependent trend (p = 
      0.003), not affected by adjustment for anti-EBV IgG titers, neither of which were 
      independently associated with relapse. There was no significant association 
      between anti-human herpesvirus IgG titers and baseline-measured disability 
      scores, or change in disability scores; however, anti-HHV-6 IgG titers were 2.8 
      times higher among progressive-course females than progressive-course males. 
      DISCUSSION: These findings suggest that, in addition to a potential etiological 
      role in MS, HHV-6 infection or the immune response to HHV-6 antigens may have an 
      effect on the risk of MS relapses and possibly on progressive courses of MS. The 
      observed effect was directly related to anti-HHV-6 IgG titers and may indicate 
      that either HHV-6 infection or factors associated with an altered humoral immune 
      response to HHV-6 may have an effect on MS clinical course. Anti-HHV-6 IgG titer 
      may be a useful prognostic factor in relapsing-remitting MS clinical course.
FAU - Simpson, Steve Jr
AU  - Simpson S Jr
AD  - 1Menzies Research Institute Tasmania, University of Tasmania, Australia.
FAU - Taylor, Bruce
AU  - Taylor B
FAU - Dwyer, Dominic E
AU  - Dwyer DE
FAU - Taylor, Janette
AU  - Taylor J
FAU - Blizzard, Leigh
AU  - Blizzard L
FAU - Ponsonby, Anne-Louise
AU  - Ponsonby AL
FAU - Pittas, Fotini
AU  - Pittas F
FAU - Dwyer, Terence
AU  - Dwyer T
FAU - van der Mei, Ingrid
AU  - van der Mei I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111114
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Antibodies, Viral)
RN  - 0 (Biomarkers)
RN  - 0 (Capsid Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*blood
MH  - Biomarkers/blood
MH  - Capsid Proteins/immunology
MH  - Disability Evaluation
MH  - Female
MH  - Herpesvirus 4, Human/immunology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Chronic 
      Progressive/blood/diagnosis/*immunology/mortality/*virology
MH  - Multiple Sclerosis, Relapsing-Remitting/blood/diagnosis/*immunology/*virology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
MH  - Tasmania
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/11/16 06:00
MHDA- 2012/09/26 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - 1352458511428081 [pii]
AID - 10.1177/1352458511428081 [doi]
PST - ppublish
SO  - Mult Scler. 2012 Jun;18(6):799-806. doi: 10.1177/1352458511428081. Epub 2011 Nov 
      14.