PMID- 22085476 OWN - NLM STAT- MEDLINE DCOM- 20120320 LR - 20221207 IS - 1399-5618 (Electronic) IS - 1398-5647 (Linking) VI - 13 IP - 7-8 DP - 2011 Nov-Dec TI - Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene. PG - 630-7 LID - 10.1111/j.1399-5618.2011.00955.x [doi] AB - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has important roles in neural cell growth and differentiation. Despite multiple lines of evidence suggesting BDNF as a possible contributor to the pathogenesis of bipolar disorder (BD), the results of genetic association studies have been mixed. We hypothesize that BDNF gene polymorphisms may confer increased susceptibility to BD. METHODS: Using a cohort of multiplex bipolar families, we performed family-based association testing to look for associations between BD and eight single nucleotide polymorphisms (SNPs) from BDNF. RESULTS: We found associations (p < 0.05) between BD and six of the eight SNPs analysed, including two SNPs not previously investigated in association studies. We were able to replicate associations previously found between BD and the Val66Met polymorphism of BDNF (rs6265) and the SNPs rs1519480 and rs12273363. We also found evidence of an association between rs11030107 and BD that was not found in a previous study. CONCLUSIONS: Our results support the hypothesis that some BDNF gene polymorphisms may be contributing factors in the pathogenesis of BD. Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD. CI - (c) 2011 John Wiley and Sons A/S. FAU - Sears, Catherine AU - Sears C AD - Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. FAU - Markie, David AU - Markie D FAU - Olds, Robin AU - Olds R FAU - Fitches, Alison AU - Fitches A LA - eng PT - Journal Article PL - Denmark TA - Bipolar Disord JT - Bipolar disorders JID - 100883596 RN - 0 (Brain-Derived Neurotrophic Factor) RN - AE28F7PNPL (Methionine) RN - HG18B9YRS7 (Valine) SB - IM MH - Bipolar Disorder/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Cohort Studies MH - Female MH - Gene Frequency MH - Genetic Association Studies MH - Genetic Predisposition to Disease/*genetics MH - Genotype MH - Humans MH - Linkage Disequilibrium MH - Male MH - Methionine/genetics MH - Polymorphism, Single Nucleotide/*genetics MH - Valine/genetics MH - White People EDAT- 2011/11/17 06:00 MHDA- 2012/03/21 06:00 CRDT- 2011/11/17 06:00 PHST- 2011/11/17 06:00 [entrez] PHST- 2011/11/17 06:00 [pubmed] PHST- 2012/03/21 06:00 [medline] AID - 10.1111/j.1399-5618.2011.00955.x [doi] PST - ppublish SO - Bipolar Disord. 2011 Nov-Dec;13(7-8):630-7. doi: 10.1111/j.1399-5618.2011.00955.x.