PMID- 22085848
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20131121
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 12
IP  - 1
DP  - 2012 Jan
TI  - Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine 
      model of allergic asthma.
PG  - 117-24
LID - 10.1016/j.intimp.2011.10.021 [doi]
AB  - Asthma is a persistent inflammatory disease characterized by airway obstruction 
      and hyperresponsiveness in association with airway inflammation. In the current 
      research, we studied the anti-inflammatory and anti-asthmatic effects of 
      tiarellic acid (TA) isolated from Tiarella polyphylla, based on asthmatic 
      parameters, such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, 
      airway hyperresponsiveness (AHR), reactive oxygen species (ROS) and mucus 
      hypersecretion, in an ovalbumin (OVA)-sensitized/challenged mouse model. TA 
      significantly inhibited increases in IgE, levels of ROS and T helper cytokines, 
      such as interleukin (IL)-4, IL-5, TNF-alpha, and IL-13, in bronchoalveolar lavage 
      fluid (BALF), and effectively suppressed airway hyperresponsiveness, 
      eosinophilia, and mucus hypersecretion in the asthmatic mouse model. In addition, 
      we found that administration of TA attenuated ovalbumin-induced increases in 
      NF-kappaB activity in lungs. The efficacy of TA was comparable to that of 
      montelukast, a currently available anti-asthmatic drug. Our results support the 
      utility of TA as a herbal medicine for asthma treatment and may have application 
      in the development of anti-inflammatory and anti-asthmatic drugs.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Lee, Mee-Young
AU  - Lee MY
AD  - Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Exporo 
      483, Yusung, Daejeon 305-811, South Korea.
FAU - Ahn, Kyung-Seop
AU  - Ahn KS
FAU - Lim, Hye-Sun
AU  - Lim HS
FAU - Yuk, Ji-Eun
AU  - Yuk JE
FAU - Kwon, Ok-Kyoung
AU  - Kwon OK
FAU - Lee, Kyoung-Youl
AU  - Lee KY
FAU - Lee, Hyeong-Kyu
AU  - Lee HK
FAU - Oh, Sei-Ryang
AU  - Oh SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111112
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (3beta,6beta-dihydroxyolean-12-en-27-oic acid)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Transcription Factor RelA)
RN  - 0 (Triterpenes)
RN  - 0 (tiarellic acid)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Asthma/chemically induced/*drug therapy/immunology/pathology
MH  - Bronchial Hyperreactivity/chemically induced/drug therapy/immunology/pathology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Eosinophilia/drug therapy/immunology
MH  - Female
MH  - Immunoglobulin E/immunology
MH  - Inflammation/chemically induced/drug therapy/immunology/pathology
MH  - Leukocyte Count
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oleanolic Acid/analogs & derivatives/pharmacology
MH  - Ovalbumin
MH  - Phytotherapy
MH  - Transcription Factor RelA/immunology
MH  - Triterpenes/*therapeutic use
EDAT- 2011/11/17 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2011/10/26 00:00 [revised]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - S1567-5769(11)00419-X [pii]
AID - 10.1016/j.intimp.2011.10.021 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2012 Jan;12(1):117-24. doi: 10.1016/j.intimp.2011.10.021. 
      Epub 2011 Nov 12.