PMID- 2208599 OWN - NLM STAT- MEDLINE DCOM- 19901114 LR - 20231213 IS - 0143-3334 (Print) IS - 0143-3334 (Linking) VI - 11 IP - 10 DP - 1990 Oct TI - Analysis of 1,3-butadiene and other selected gas-phase components in cigarette mainstream and sidestream smoke by gas chromatography-mass selective detection. PG - 1863-8 AB - An analytical procedure was developed for the analysis of 1,3-butadiene, acrolein, isoprene, benzene and toluene in the gas phase of cigarette smoke and environmental tobacco smoke (ETS) utilizing cryogenic gas chromatography-mass selective detection (GC-MSD). The MSD was operated in the selective ion monitoring (SIM) mode. The compounds of interest eluted in less than 15 min. The gas phase of freshly generated mainstream smoke was introduced into the GC-MSD via a 10-port gas sampling valve on a puff-by-puff basis. This method minimizes the ageing of tobacco smoke. The levels of 1,3-butadiene in the mainstream smoke ranged from 16 to 75 micrograms/cigarette. The gas phase of sidestream smoke was trapped in methanol using three midget impingers at -78 degrees C. The amount of 1,3-butadiene in the sidestream smoke ranged from 205-361 micrograms/cigarette. The concentration of 1,3-butadiene in ETS in a smoke-filled bar amounted to 2.7-4.5 micrograms/m3. FAU - Brunnemann, K D AU - Brunnemann KD AD - Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY 10595. FAU - Kagan, M R AU - Kagan MR FAU - Cox, J E AU - Cox JE FAU - Hoffmann, D AU - Hoffmann D LA - eng GR - CA-29580/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - Carcinogenesis JT - Carcinogenesis JID - 8008055 RN - 0 (Butadienes) RN - 0 (Carcinogens) RN - 0 (Hemiterpenes) RN - 0 (Mutagens) RN - 0 (Pentanes) RN - 0 (Smoke) RN - 0A62964IBU (isoprene) RN - 3FPU23BG52 (Toluene) RN - 7864XYD3JJ (Acrolein) RN - J64922108F (Benzene) RN - JSD5FGP5VD (1,3-butadiene) SB - IM MH - Acrolein/analysis MH - Benzene/analysis MH - Butadienes/*analysis MH - Carcinogens/*analysis MH - Gas Chromatography-Mass Spectrometry/methods MH - *Hemiterpenes MH - Mutagens/*analysis MH - *Pentanes MH - *Plants, Toxic MH - Smoke/*analysis MH - *Nicotiana MH - Toluene/analysis EDAT- 1990/10/01 00:00 MHDA- 1990/10/01 00:01 CRDT- 1990/10/01 00:00 PHST- 1990/10/01 00:00 [pubmed] PHST- 1990/10/01 00:01 [medline] PHST- 1990/10/01 00:00 [entrez] AID - 10.1093/carcin/11.10.1863 [doi] PST - ppublish SO - Carcinogenesis. 1990 Oct;11(10):1863-8. doi: 10.1093/carcin/11.10.1863.